Neurofibromin: Difference between revisions

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<scene name='90/904325/Arginine_finger_and_gtp/1'>The arginine finger stabilizes glutamine which assists the cleaving mechanism.</scene>

====Conformations====

Neurofibromin is a dimeric protein that is found in the cytoplasm. It exists in two conformations, <scene name='90/904326/Open_conformation/2'>open</scene>, and <scene name='90/904326/Closed_conformation/2'>closed</scene> . The open conformation has one of the protomers in an auto-inhibited conformation and the other in an open conformation. In the open conformation, Ras is able to bind to neurofibromin. The closed conformation has both protomers in an autoinhibited conformation, which sterically hinders the binding of Ras.

Neurofibromin is a dimeric protein that is found in the cytoplasm. It exists in two conformations, <scene name='90/904326/Open_conformation/2'>open</scene> and <scene name='90/904326/Closed_conformation/2'>closed</scene> . The open conformation has one of the protomers in an auto-inhibited conformation and the other in an open conformation. In the open conformation, Ras is able to bind to neurofibromin. The closed conformation has both protomers in an autoinhibited conformation, which sterically hinders the binding of Ras.

==RAS Complex==

<scene name='90/904325/Ras_nf1_complex/2'>NF interacts with Ras to form a complex. R68 assists N61 in catalysis.</scene>

Neurofibromin: Difference between revisions

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@@ Line 18: / Line 18: @@
 <scene name='90/904325/Arginine_finger_and_gtp/1'>The arginine finger stabilizes glutamine which assists the cleaving mechanism.</scene>
 ====Conformations====
-Neurofibromin is a dimeric protein that is found in the cytoplasm. It exists in two conformations, <scene name='90/904326/Open_conformation/2'>open</scene>, and <scene name='90/904326/Closed_conformation/2'>closed</scene> . The open conformation has one of the protomers in an auto-inhibited conformation and the other in an open conformation. In the open conformation, Ras is able to bind to neurofibromin. The closed conformation has both protomers in an autoinhibited conformation, which sterically hinders the binding of Ras.
+Neurofibromin is a dimeric protein that is found in the cytoplasm. It exists in two conformations, <scene name='90/904326/Open_conformation/2'>open</scene> and <scene name='90/904326/Closed_conformation/2'>closed</scene> . The open conformation has one of the protomers in an auto-inhibited conformation and the other in an open conformation. In the open conformation, Ras is able to bind to neurofibromin. The closed conformation has both protomers in an autoinhibited conformation, which sterically hinders the binding of Ras.
 ==RAS Complex==
 <scene name='90/904325/Ras_nf1_complex/2'>NF interacts with Ras to form a complex. R68 assists N61 in catalysis.</scene>