Neurofibromin: Difference between revisions
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<scene name='90/904325/Arginine_finger_and_gtp/1'>The arginine finger stabilizes glutamine which assists the cleaving mechanism.</scene> | <scene name='90/904325/Arginine_finger_and_gtp/1'>The arginine finger stabilizes glutamine which assists the cleaving mechanism.</scene> | ||
====Conformations==== | ====Conformations==== | ||
Neurofibromin is a dimeric protein that is found in the cytoplasm. It exists in two conformations, <scene name='90/904326/Open_conformation/2'>open</scene> and <scene name='90/904326/Closed_conformation/2'>closed</scene> . The open conformation has one of the protomers in an auto-inhibited conformation and the other in an open conformation. In the open conformation, Ras is able to bind to neurofibromin. The closed conformation has both protomers in an autoinhibited conformation, which sterically hinders the binding of Ras. | Neurofibromin is a dimeric protein that is found in the cytoplasm. It exists in two conformations, <scene name='90/904326/Open_conformation/2'>open</scene> and <scene name='90/904326/Closed_conformation/2'>closed</scene> . The open conformation has one of the protomers in an auto-inhibited conformation and the other in an open conformation. In the <scene name='90/904326/Open_conformation_with_grd_hig/2'>open conformation</scene>, Ras is able to bind to the GRD neurofibromin. The <scene name='90/904326/Grd_closed_conformation/2'>closed conformation</scene> has both protomers in an autoinhibited conformation, which sterically hinders the binding of Ras to GRD. | ||
==RAS Complex== | ==RAS Complex== | ||
<scene name='90/904325/Ras_nf1_complex/2'>NF interacts with Ras to form a complex. R68 assists N61 in catalysis.</scene> | <scene name='90/904325/Ras_nf1_complex/2'>NF interacts with Ras to form a complex. R68 assists N61 in catalysis.</scene> | ||
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
<scene name='90/904326/Sec15ph_and_grd_open/2'>sec14ph domain in Open Conformation</scene> | <scene name='90/904326/Sec15ph_and_grd_open/2'>sec14ph domain in Open Conformation</scene> | ||
<scene name='90/904326/Sec14ph_and_grd_closed/2'>sec14ph domain in Closed Conformation</scene> | <scene name='90/904326/Sec14ph_and_grd_closed/2'>sec14ph domain in Closed Conformation</scene> | ||
