Sandbox Reserved 1705: Difference between revisions

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== Introduction ==

Anaplastic lymphoma kinase is a receptor tyrosine kinase (RTK) that is important in regulating functions within the central nervous system <ref name="Reshetnyak">PMID:34819673</ref>. The route to discovery of this protein's structure was rather complex, spanning almost 20 years; the kinase domain was discovered in 1994, the full protein structure in 1997, and the ligand structures in 2014. These structures were found using [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryo-electron microscopy],[https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance_spectroscopy nuclear magnetic resonance], and [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray crystallography]. Anaplastic lymphoma kinase is a proto-oncogene with mutations associated with various types of cancers, including non-small-cell lung cancer, anaplastic large cell lymphoma, squamous cell carcinoma, and inflammatory myofibroblastic cancer <ref name="Palmer">PMID:19459784</ref>.

Anaplastic lymphoma kinase is a [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase] (RTK) that is important in regulating functions within the central nervous system <ref name="Reshetnyak">PMID:34819673</ref>. The route to discovery of this protein's structure was rather complex, spanning almost 20 years; the kinase domain was discovered in 1994, the full protein structure in 1997, and the ligand structures in 2014. These structures were found using [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryo-electron microscopy],[https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance_spectroscopy nuclear magnetic resonance], and [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray crystallography]. Anaplastic lymphoma kinase is a proto-oncogene with mutations associated with various types of cancers, including non-small-cell lung cancer, anaplastic large cell lymphoma, squamous cell carcinoma, and inflammatory myofibroblastic cancer <ref name="Palmer">PMID:19459784</ref>.

== General Structure ==

Sandbox Reserved 1705: Difference between revisions

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 == Introduction ==
-Anaplastic lymphoma kinase is a receptor tyrosine kinase (RTK) that is important in regulating functions within the central nervous system <ref name="Reshetnyak">PMID:34819673</ref>. The route to discovery of this protein's structure was rather complex, spanning almost 20 years; the kinase domain was discovered in 1994, the full protein structure in 1997, and the ligand structures in 2014. These structures were found using [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryo-electron microscopy],[https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance_spectroscopy nuclear magnetic resonance], and [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray crystallography]. Anaplastic lymphoma kinase is a proto-oncogene with mutations associated with various types of cancers, including non-small-cell lung cancer, anaplastic large cell lymphoma, squamous cell carcinoma, and inflammatory myofibroblastic cancer <ref name="Palmer">PMID:19459784</ref>.
+Anaplastic lymphoma kinase is a [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase] (RTK) that is important in regulating functions within the central nervous system <ref name="Reshetnyak">PMID:34819673</ref>. The route to discovery of this protein's structure was rather complex, spanning almost 20 years; the kinase domain was discovered in 1994, the full protein structure in 1997, and the ligand structures in 2014. These structures were found using [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryo-electron microscopy],[https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance_spectroscopy nuclear magnetic resonance], and [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray crystallography]. Anaplastic lymphoma kinase is a proto-oncogene with mutations associated with various types of cancers, including non-small-cell lung cancer, anaplastic large cell lymphoma, squamous cell carcinoma, and inflammatory myofibroblastic cancer <ref name="Palmer">PMID:19459784</ref>.
 == General Structure ==