Neurofibromin: Difference between revisions

Line 1:

== Introduction ==

Neurofibromin (NF) is a cytoplasmic protein encoded by the ''NF1'' gene located on chromosome 17 <ref name= ''Bergoug''>PMID:33121128</ref>. The neurofibromin protein in encoded by over 350 kb of DNA and contains 62 exons, 58 of ~~whihc~~ are constitutive<ref name= ''Trovó-Marqui''>PMID:16813595</ref>. NF suppresses the [https://proteopedia.org/wiki/index.php/GTPase_HRas "Ras"] oncogene by increasing the rate of hydrolysis from <scene name='90/904325/Ras_full_structure/2'>Ras-GTP</scene> (active) to Ras-GDP (inactive)<ref name= ''Hall''>PMID:12213964</ref>. Increasing the rate of Ras inactivation decreases cell proliferation linked to cancer<ref name= ''Cimino''>PMID:29478615</ref>.

Neurofibromin (NF) is a cytoplasmic protein encoded by the ''NF1'' gene located on chromosome 17 <ref name= ''Bergoug''>PMID:33121128</ref>. The neurofibromin protein in encoded by over 350 kb of DNA and contains 62 exons, 58 of which are constitutive<ref name= ''Trovó-Marqui''>PMID:16813595</ref>. NF suppresses the [https://proteopedia.org/wiki/index.php/GTPase_HRas "Ras"] oncogene by increasing the rate of hydrolysis from <scene name='90/904325/Ras_full_structure/2'>Ras-GTP</scene> (active) to Ras-GDP (inactive)<ref name= ''Hall''>PMID:12213964</ref>. Increasing the rate of Ras inactivation decreases cell proliferation linked to cancer<ref name= ''Cimino''>PMID:29478615</ref>.

== Structure ==

Neurofibromin: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
 <StructureSection load='' scene='90/904325/Introductory_image_full/1' size='340' side='right' caption='Neurofibromin'>
 == Introduction ==
-Neurofibromin (NF) is a cytoplasmic protein encoded by the ''NF1'' gene located on chromosome 17 <ref name= ''Bergoug''>PMID:33121128</ref>. The neurofibromin protein in encoded by over 350 kb of DNA and contains 62 exons, 58 of whihc are constitutive<ref name= ''Trovó-Marqui''>PMID:16813595</ref>. NF suppresses the [https://proteopedia.org/wiki/index.php/GTPase_HRas "Ras"] oncogene by increasing the rate of hydrolysis from <scene name='90/904325/Ras_full_structure/2'>Ras-GTP</scene> (active) to Ras-GDP (inactive)<ref name= ''Hall''>PMID:12213964</ref>. Increasing the rate of Ras inactivation decreases cell proliferation linked to cancer<ref name= ''Cimino''>PMID:29478615</ref>.
+Neurofibromin (NF) is a cytoplasmic protein encoded by the ''NF1'' gene located on chromosome 17 <ref name= ''Bergoug''>PMID:33121128</ref>. The neurofibromin protein in encoded by over 350 kb of DNA and contains 62 exons, 58 of which are constitutive<ref name= ''Trovó-Marqui''>PMID:16813595</ref>. NF suppresses the [https://proteopedia.org/wiki/index.php/GTPase_HRas "Ras"] oncogene by increasing the rate of hydrolysis from <scene name='90/904325/Ras_full_structure/2'>Ras-GTP</scene> (active) to Ras-GDP (inactive)<ref name= ''Hall''>PMID:12213964</ref>. Increasing the rate of Ras inactivation decreases cell proliferation linked to cancer<ref name= ''Cimino''>PMID:29478615</ref>.
 == Structure ==