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<scene name='90/904321/Vitamin_k_epoxide_reductase/1'>Vitamin K Epoxide Reductase</scene>

[https://en.wikipedia.org/wiki/Vitamin_K_epoxide_reductase VKOR WIKI](VKOR) is an endoplasmic membrane enzyme that generates the active form of Vitamin K to support blood coagulation. VKOR homologs are integral membrane thiol oxidoreductases [https://en.wikipedia.org/wiki/Thiol_oxidoreductase Thiol OxidoReductase] due to the function of VKOR being dependent on thiol residues and disulfide bonding. The Vitamin K Cycle and the VKOR enzyme specifically are common drug targets for thromboembolic diseases. This is because, as pictured, the vitamin K cycle is required to activate blood coagulant factors [https://en.wikipedia.org/wiki/Thrombin II],  [https://en.wikipedia.org/wiki/Coagulation_factor_VII VII], [https://en.wikipedia.org/wiki/Factor_IX IX], and [https://en.wikipedia.org/wiki/Factor_X#:~:text=Factor%20X%2C%20also%20known%20by,vitamin%20K%20for%20its%20synthesis. X]. Coagulant factor activation promotes blood clotting, which in high amounts can be dangerous and cause thromboembolic diseases such as stroke, deep vein thrombosis, and/or pulmonary embolism. Vitamin K Epoxide Reductase is found and primarily synthesized in the liver. It is embedded in the membrane known as the endoplasmic reticulum.

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