Neurofibromin: Difference between revisions

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===Important Structural Features===

====Conformations====

Neurofibromin is a dimeric protein ~~that is found in the cytoplasm~~. It exists in two conformations, <scene name='90/904326/Open_conformation/2'>open</scene> and <scene name='90/904326/Closed_conformation/2'>closed</scene> . The open conformation has one of the protomers in an auto-inhibited conformation and the other in an open conformation. In the <scene name='90/904326/Open_conformation_with_grd_hig/2'>open conformation</scene>, Ras is able to bind to the GRD neurofibromin. The <scene name='90/904326/Grd_closed_conformation/2'>closed conformation</scene> has both protomers in an autoinhibited conformation, which sterically hinders the binding of Ras to GRD. Only one of the protomers has to be in the open conformation for Ras to bind.

Neurofibromin is a dimeric protein. It exists in two conformations, <scene name='90/904326/Open_conformation/2'>open</scene> and <scene name='90/904326/Closed_conformation/2'>closed</scene> . The open conformation has one of the protomers in an auto-inhibited conformation and the other in an open conformation. In the <scene name='90/904326/Open_conformation_with_grd_hig/2'>open conformation</scene>, Ras is able to bind to the GRD neurofibromin. The <scene name='90/904326/Grd_closed_conformation/2'>closed conformation</scene> has both protomers in an autoinhibited conformation, which sterically hinders the binding of Ras to GRD. Only one of the protomers has to be in the open conformation for Ras to bind.

====SPRED-1 Protein====

The SPRED-1 protein <scene name='90/904325/Nf1_ras_spred1/1'>localizes neurofibromin</scene> to the cell membrane in to allow it to bind to the membrane oriented Ras protein<ref name= ''Naschberger''>PMID:34707296</ref>. SPRED-1 interacts with the N-terminal domain of NF to guide it to the membrane from the cytosol, where its C terminal domain will determine its target <ref name= ''Dunzendorfer-Matt''>PMID:27313208</ref>.

Neurofibromin: Difference between revisions

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@@ Line 15: / Line 15: @@
 ===Important Structural Features===
 ====Conformations====
-Neurofibromin is a dimeric protein that is found in the cytoplasm. It exists in two conformations, <scene name='90/904326/Open_conformation/2'>open</scene> and <scene name='90/904326/Closed_conformation/2'>closed</scene> . The open conformation has one of the protomers in an auto-inhibited conformation and the other in an open conformation. In the <scene name='90/904326/Open_conformation_with_grd_hig/2'>open conformation</scene>, Ras is able to bind to the GRD neurofibromin. The <scene name='90/904326/Grd_closed_conformation/2'>closed conformation</scene> has both protomers in an autoinhibited conformation, which sterically hinders the binding of Ras to GRD. Only one of the protomers has to be in the open conformation for Ras to bind.
+Neurofibromin is a dimeric protein. It exists in two conformations, <scene name='90/904326/Open_conformation/2'>open</scene> and <scene name='90/904326/Closed_conformation/2'>closed</scene> . The open conformation has one of the protomers in an auto-inhibited conformation and the other in an open conformation. In the <scene name='90/904326/Open_conformation_with_grd_hig/2'>open conformation</scene>, Ras is able to bind to the GRD neurofibromin. The <scene name='90/904326/Grd_closed_conformation/2'>closed conformation</scene> has both protomers in an autoinhibited conformation, which sterically hinders the binding of Ras to GRD. Only one of the protomers has to be in the open conformation for Ras to bind.
 ====SPRED-1 Protein====
 The SPRED-1 protein <scene name='90/904325/Nf1_ras_spred1/1'>localizes neurofibromin</scene> to the cell membrane in to allow it to bind to the membrane oriented Ras protein<ref name= ''Naschberger''>PMID:34707296</ref>. SPRED-1 interacts with the N-terminal domain of NF to guide it to the membrane from the cytosol, where its C terminal domain will determine its target <ref name= ''Dunzendorfer-Matt''>PMID:27313208</ref>.