Sandbox Reserved 1705: Difference between revisions

Line 6:

== Introduction ==

[[Image:ALK_Domain_Outline.png|350 px|right|thumb|Figure 1. Outline of the domains and regions of anaplastic lymphoma kinase]]

Anaplastic lymphoma kinase is a [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase] (RTK) that is important in regulating functions within the central nervous system <ref name="Reshetnyak">PMID:34819673</ref>. ALK activates many pathways including the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway ERK], [https://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway JAK], and [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K] pathways, all of which are involved in proliferation, migration, and cell survival~~. RTKs are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones~~. The route to discovery of this protein's structure was rather complex, spanning almost 20 years; the kinase domain was discovered in 1994, the full protein structure in 1997, and the ligand structures in 2014. These structures were found using [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryo-electron microscopy],[https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance_spectroscopy nuclear magnetic resonance], and [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray crystallography]. Anaplastic lymphoma kinase is a proto-oncogene with mutations associated with various types of cancers, including non-small-cell lung cancer, anaplastic large cell lymphoma, squamous cell carcinoma, and inflammatory myofibroblastic cancer <ref name="Palmer">PMID:19459784</ref>. ALK is a referred to as a proto-oncogene because certain mutations in it's protein sequence are known to have a strong positive association with the development of cancerous cells.

Anaplastic lymphoma kinase is a [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase] (RTK) that is important in regulating functions within the central nervous system <ref name="Reshetnyak">PMID:34819673</ref>. RTKs are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. ALK activates many pathways including the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway ERK], [https://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway JAK], and [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K] pathways, all of which are involved in proliferation, migration, and cell survival. The route to discovery of this protein's structure was rather complex, spanning almost 20 years; the kinase domain was discovered in 1994, the full protein structure in 1997, and the ligand structures in 2014. These structures were found using [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryo-electron microscopy],[https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance_spectroscopy nuclear magnetic resonance], and [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray crystallography]. Anaplastic lymphoma kinase is a proto-oncogene with mutations associated with various types of cancers, including non-small-cell lung cancer, anaplastic large cell lymphoma, squamous cell carcinoma, and inflammatory myofibroblastic cancer <ref name="Palmer">PMID:19459784</ref>. ALK is a referred to as a proto-oncogene because certain mutations in it's protein sequence are known to have a strong positive association with the development of cancerous cells.

== General Structure ==

Sandbox Reserved 1705: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 6: / Line 6: @@
 == Introduction ==
 [[Image:ALK_Domain_Outline.png|350 px|right|thumb|Figure 1. Outline of the domains and regions of anaplastic lymphoma kinase]]
-Anaplastic lymphoma kinase is a [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase] (RTK) that is important in regulating functions within the central nervous system <ref name="Reshetnyak">PMID:34819673</ref>. ALK activates many pathways including the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway ERK], [https://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway JAK], and [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K] pathways, all of which are involved in proliferation, migration, and cell survival. RTKs are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. The route to discovery of this protein's structure was rather complex, spanning almost 20 years; the kinase domain was discovered in 1994, the full protein structure in 1997, and the ligand structures in 2014. These structures were found using [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryo-electron microscopy],[https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance_spectroscopy nuclear magnetic resonance], and [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray crystallography]. Anaplastic lymphoma kinase is a proto-oncogene with mutations associated with various types of cancers, including non-small-cell lung cancer, anaplastic large cell lymphoma, squamous cell carcinoma, and inflammatory myofibroblastic cancer <ref name="Palmer">PMID:19459784</ref>. ALK is a referred to as a proto-oncogene because certain mutations in it's protein sequence are known to have a strong positive association with the development of cancerous cells.
+Anaplastic lymphoma kinase is a [https://en.wikipedia.org/wiki/Receptor_tyrosine_kinase receptor tyrosine kinase] (RTK) that is important in regulating functions within the central nervous system <ref name="Reshetnyak">PMID:34819673</ref>. RTKs are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. ALK activates many pathways including the [https://en.wikipedia.org/wiki/MAPK/ERK_pathway ERK], [https://en.wikipedia.org/wiki/JAK-STAT_signaling_pathway JAK], and [https://en.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway PI3K] pathways, all of which are involved in proliferation, migration, and cell survival. The route to discovery of this protein's structure was rather complex, spanning almost 20 years; the kinase domain was discovered in 1994, the full protein structure in 1997, and the ligand structures in 2014. These structures were found using [https://en.wikipedia.org/wiki/Cryogenic_electron_microscopy cryo-electron microscopy],[https://en.wikipedia.org/wiki/Nuclear_magnetic_resonance_spectroscopy nuclear magnetic resonance], and [https://en.wikipedia.org/wiki/X-ray_crystallography X-ray crystallography]. Anaplastic lymphoma kinase is a proto-oncogene with mutations associated with various types of cancers, including non-small-cell lung cancer, anaplastic large cell lymphoma, squamous cell carcinoma, and inflammatory myofibroblastic cancer <ref name="Palmer">PMID:19459784</ref>. ALK is a referred to as a proto-oncogene because certain mutations in it's protein sequence are known to have a strong positive association with the development of cancerous cells.
 == General Structure ==