Sandbox Reserved 1717: Difference between revisions

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Warfarin still forms Hydrogen bonds with <scene name='90/904322/Tyr_asn_binding_warfarin/2'>Asn80 and Tyr139</scene>. The specific bonds are between Asn80 and the 2-ketone group of warfarin and Tyr139 with the 4-hydroxyl group of warfarin. The rest of the pocket is hydrophobic interactions. The H bonds are necessary for the recognition of the ligand in the binding site of VKOR.

There is a slight difference in the way in which warfarin binds compared to VKO. Warfarin binds are a slightly different angle. This creates a difference in how the cap loop and anchor domain interact, and that noticeable difference is with <scene name='90/904322/Arg58/3'>Arg58</scene>. With VKO, Arg58, located in the cap loop, directly interacts with <scene name='90/904322/Arg58_vko/5'>Glu67</scene> when VKO is bound. When warfarin binds, Arg58 is found inserted between <scene name='90/904322/Arg58_warfarin/1'>Glu67 and His68</scene> of the anchor domain.

There is a slight difference in the way in which warfarin binds compared to VKO. Warfarin binds are a slightly different angle. This creates a difference in how the cap loop and anchor domain interact, and that noticeable difference is with <scene name='90/904322/Arg58/3'>Arg58</scene>. With VKO, Arg58, located in the cap loop, directly interacts with <scene name='90/904322/Arg58_vko/3'>Glu67</scene> when VKO is bound. When warfarin binds, Arg58 is found inserted between<scene name='90/904322/Arg58_warfarin/2'>Glu67 and His68</scene> of the anchor domain.

=== Disease ===

Sandbox Reserved 1717: Difference between revisions

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@@ Line 69: / Line 69: @@
 Warfarin still forms Hydrogen bonds with <scene name='90/904322/Tyr_asn_binding_warfarin/2'>Asn80 and Tyr139</scene>. The specific bonds are between Asn80 and the 2-ketone group of warfarin and Tyr139 with the 4-hydroxyl group of warfarin. The rest of the pocket is hydrophobic interactions. The H bonds are necessary for the recognition of the ligand in the binding site of VKOR.
-There is a slight difference in the way in which warfarin binds compared to VKO. Warfarin binds are a slightly different angle. This creates a difference in how the cap loop and anchor domain interact, and that noticeable difference is with <scene name='90/904322/Arg58/3'>Arg58</scene>. With VKO, Arg58, located in the cap loop, directly interacts with <scene name='90/904322/Arg58_vko/5'>Glu67</scene> when VKO is bound. When warfarin binds, Arg58 is found inserted between <scene name='90/904322/Arg58_warfarin/1'>Glu67 and His68</scene> of the anchor domain.
+There is a slight difference in the way in which warfarin binds compared to VKO. Warfarin binds are a slightly different angle. This creates a difference in how the cap loop and anchor domain interact, and that noticeable difference is with <scene name='90/904322/Arg58/3'>Arg58</scene>. With VKO, Arg58, located in the cap loop, directly interacts with <scene name='90/904322/Arg58_vko/3'>Glu67</scene> when VKO is bound. When warfarin binds, Arg58 is found inserted between<scene name='90/904322/Arg58_warfarin/2'>Glu67 and His68</scene> of the anchor domain.
 === Disease ===