Sandbox Reserved 1717: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 69: | Line 69: | ||
Warfarin still forms Hydrogen bonds with <scene name='90/904322/Tyr_asn_binding_warfarin/2'>Asn80 and Tyr139</scene>. The specific bonds are between Asn80 and the 2-ketone group of warfarin and Tyr139 with the 4-hydroxyl group of warfarin. The rest of the pocket is hydrophobic interactions. The H bonds are necessary for the recognition of the ligand in the binding site of VKOR. | Warfarin still forms Hydrogen bonds with <scene name='90/904322/Tyr_asn_binding_warfarin/2'>Asn80 and Tyr139</scene>. The specific bonds are between Asn80 and the 2-ketone group of warfarin and Tyr139 with the 4-hydroxyl group of warfarin. The rest of the pocket is hydrophobic interactions. The H bonds are necessary for the recognition of the ligand in the binding site of VKOR. | ||
There is a slight difference in the way in which warfarin binds compared to VKO. Warfarin binds are a slightly different angle. This creates a difference in how the cap loop and anchor domain interact, and that noticeable difference is with <scene name='90/904322/Arg58/ | There is a slight difference in the way in which warfarin binds compared to VKO. Warfarin binds are a slightly different angle. This creates a difference in how the cap loop and anchor domain interact, and that noticeable difference is with <scene name='90/904322/Arg58/4'>Arg58</scene>. With VKO, Arg58, located in the cap loop, directly interacts with <scene name='90/904322/Arg58_vko/5'>Glu67</scene> when VKO is bound. When warfarin binds, Arg58 is found inserted between<scene name='90/904322/Arg58_warfarin/2'>Glu67 and His68</scene> of the anchor domain. | ||
=== Disease === | === Disease === | ||
