3i82

Ethanolamine Utilization Microcompartment Shell Subunit, EutL Closed Form

spinqualitylabelsall models 3i82, resolution 2.31Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3i82 is a 1 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3i6p, 3i71, 3i87, 3i96, 3ia0 Gene: b2439, eutL, JW2432, yffJ (ECOLI) Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [EUTL_ECOLI] May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Many bacterial cells contain proteinaceous microcompartments that act as simple organelles by sequestering specific metabolic processes involving volatile or toxic metabolites. Here we report the three-dimensional (3D) crystal structures, with resolutions between 1.65 and 2.5 angstroms, of the four homologous proteins (EutS, EutL, EutK, and EutM) that are thought to be the major shell constituents of a functionally complex ethanolamine utilization (Eut) microcompartment. The Eut microcompartment is used to sequester the metabolism of ethanolamine in bacteria such as Escherichia coli and Salmonella enterica. The four Eut shell proteins share an overall similar 3D fold, but they have distinguishing structural features that help explain the specific roles they play in the microcompartment. For example, EutL undergoes a conformational change that is probably involved in gating molecular transport through shell protein pores, whereas structural evidence suggests that EutK might bind a nucleic acid component. Together these structures give mechanistic insight into bacterial microcompartments. Structure and mechanisms of a protein-based organelle in Escherichia coli.,Tanaka S, Sawaya MR, Yeates TO Science. 2010 Jan 1;327(5961):81-4. PMID:20044574 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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