Sandbox Reserved 1703: Difference between revisions

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===Active State===

Upon binding of the PAM, helix VI is shifted downward in the TMD. This downward shift induces a reorientation of the TMD from its original TM3-TM4 asymmetric dimer interface in the inactive form to an <scene name='90/904308/~~Active_7_tm~~/1'>TM6-TM6 ~~asymmetric dimer~~ interface</scene>. The downward shift of helix VI is crucial for the receptor’s transformation from the inactive to the active form for 2 main reasons: (1) reorientation breaks key interactions in the TMD that stabilize the inactive form and (2) repositioning <scene name='90/904308/Active_structure/4'>intracellular loops</scene> of in the TMD to assist in the binding and recognitions of the <scene name='90/904308/G-protein/1'>G-Protein</scene>. The G-protein is made up of three subunits: <scene name='90/904308/Alpha_subunit/1'>α-subunit</scene>, <scene name='90/904308/Beta_subunit/1'>β-subunit</scene>, and a <scene name='90/904308/Gamma_subunit/1'>γ-subunit</scene>.

Upon binding of the PAM, helix VI is shifted downward in the TMD. This downward shift induces a reorientation of the TMD from its original TM3-TM4 asymmetric dimer interface in the inactive form to an <scene name='90/904308/Active_7_tm_transparent/1'>asymmetric TM6-TM6 interface</scene>. The downward shift of helix VI is crucial for the receptor’s transformation from the inactive to the active form for 2 main reasons: (1) reorientation breaks key interactions in the TMD that stabilize the inactive form and (2) repositioning <scene name='90/904308/Active_structure/4'>intracellular loops</scene> of in the TMD to assist in the binding and recognitions of the <scene name='90/904308/G-protein/1'>G-Protein</scene>. The G-protein is made up of three subunits: <scene name='90/904308/Alpha_subunit/1'>α-subunit</scene>, <scene name='90/904308/Beta_subunit/1'>β-subunit</scene>, and a <scene name='90/904308/Gamma_subunit/1'>γ-subunit</scene>.

====G-Protein Recognition====

Sandbox Reserved 1703: Difference between revisions

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@@ Line 28: / Line 28: @@
 ===Active State===
-Upon binding of the PAM, helix VI is shifted downward in the TMD. This downward shift induces a reorientation of the TMD from its original TM3-TM4 asymmetric dimer interface in the inactive form to an <scene name='90/904308/Active_7_tm/1'>TM6-TM6 asymmetric dimer interface</scene>. The downward shift of helix VI is crucial for the receptor’s transformation from the inactive to the active form for 2 main reasons: (1) reorientation breaks key interactions in the TMD that stabilize the inactive form and (2) repositioning <scene name='90/904308/Active_structure/4'>intracellular loops</scene> of in the TMD to assist in the binding and recognitions of the <scene name='90/904308/G-protein/1'>G-Protein</scene>. The G-protein is made up of three subunits: <scene name='90/904308/Alpha_subunit/1'>α-subunit</scene>, <scene name='90/904308/Beta_subunit/1'>β-subunit</scene>, and a <scene name='90/904308/Gamma_subunit/1'>γ-subunit</scene>.
+Upon binding of the PAM, helix VI is shifted downward in the TMD. This downward shift induces a reorientation of the TMD from its original TM3-TM4 asymmetric dimer interface in the inactive form to an <scene name='90/904308/Active_7_tm_transparent/1'>asymmetric TM6-TM6 interface</scene>. The downward shift of helix VI is crucial for the receptor’s transformation from the inactive to the active form for 2 main reasons: (1) reorientation breaks key interactions in the TMD that stabilize the inactive form and (2) repositioning <scene name='90/904308/Active_structure/4'>intracellular loops</scene> of in the TMD to assist in the binding and recognitions of the <scene name='90/904308/G-protein/1'>G-Protein</scene>. The G-protein is made up of three subunits: <scene name='90/904308/Alpha_subunit/1'>α-subunit</scene>, <scene name='90/904308/Beta_subunit/1'>β-subunit</scene>, and a <scene name='90/904308/Gamma_subunit/1'>γ-subunit</scene>.
 ====G-Protein Recognition====