Neurofibromin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 35: | Line 35: | ||
==Downstream Effects== | ==Downstream Effects== | ||
[[Image: | [[Image:signaling_pathway_for_ras.jpg|500 px|right|thumb|Figure 2: Downstream proliferation of Ras signals have a variety of impacts, including gene regulation, cell proliferation, and cell growth; By cybertory - This file was derived from: Signal transduction v1.png, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=12081090]] | ||
Misregulated [https://proteopedia.org/wiki/index.php/GTPase_HRas Ras activity] can lead to uncontrolled signaling in many different cell signaling pathways. Figure 2 provides an overview of the pathways that are connected to Ras. As shown, neurofibromin's ability to regulate Ras activity can alter cell proliferation signaling, activation/ inactivation of transcription factors, and cell apoptotic factors, making its proper functioning crucial <ref name= ''McCubrey''>PMID:17126425</ref>. Additionally, due to its overall importance in multiple cell pathways, neither neurofibromin nor Ras profile as possible drug targets. | Misregulated [https://proteopedia.org/wiki/index.php/GTPase_HRas Ras activity] can lead to uncontrolled signaling in many different cell signaling pathways. Figure 2 provides an overview of the pathways that are connected to Ras. As shown, neurofibromin's ability to regulate Ras activity can alter cell proliferation signaling, activation/ inactivation of transcription factors, and cell apoptotic factors, making its proper functioning crucial <ref name= ''McCubrey''>PMID:17126425</ref>. Additionally, due to its overall importance in multiple cell pathways, neither neurofibromin nor Ras profile as possible drug targets. | ||
