Neurofibromin: Difference between revisions
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<StructureSection load='' scene='90/904325/Introductory_image_full/ | <StructureSection load='' scene='90/904325/Introductory_image_full/2' size='340' side='right' caption='Neurofibromin [https://www.rcsb.org/structure/7PGS (7pgs)] Homo dimeric structure colored to differentiate dimers'> | ||
== Introduction == | == Introduction == | ||
<scene name='90/904325/Introductory_image_full/1'>Neurofibromin</scene> (NF) is a cytoplasmic protein encoded by the ''NF1'' gene located on chromosome 17 <ref name= ''Bergoug''>PMID:33121128</ref>. It is localized to the cell membrane by the [https://en.wikipedia.org/wiki/SPRED1 SPRED 1] protein<ref name= ''Naschberger''>PMID:34707296</ref>. The neurofibromin protein in encoded by over 350 kb of DNA and contains 62 exons, 58 of which are constitutive<ref name= ''Trovó-Marqui''>PMID:16813595</ref>. NF suppresses the [https://proteopedia.org/wiki/index.php/GTPase_HRas Ras] oncogene by increasing the rate of hydrolysis from <scene name='90/904325/Ras_full_structure/2'>Ras-GTP</scene> (active) to <scene name='90/904325/Arginine_finger_and_gdp/2'>Ras-GDP</scene> (inactive)<ref name= ''Hall''>PMID:12213964</ref>. Increasing the rate of Ras inactivation decreases cell proliferation linked to cancer<ref name= ''Cimino''>PMID:29478615</ref>. | <scene name='90/904325/Introductory_image_full/1'>Neurofibromin</scene> (NF) is a cytoplasmic protein encoded by the ''NF1'' gene located on chromosome 17 <ref name= ''Bergoug''>PMID:33121128</ref>. It is localized to the cell membrane by the [https://en.wikipedia.org/wiki/SPRED1 SPRED 1] protein<ref name= ''Naschberger''>PMID:34707296</ref>. The neurofibromin protein in encoded by over 350 kb of DNA and contains 62 exons, 58 of which are constitutive<ref name= ''Trovó-Marqui''>PMID:16813595</ref>. NF suppresses the [https://proteopedia.org/wiki/index.php/GTPase_HRas Ras] oncogene by increasing the rate of hydrolysis from <scene name='90/904325/Ras_full_structure/2'>Ras-GTP</scene> (active) to <scene name='90/904325/Arginine_finger_and_gdp/2'>Ras-GDP</scene> (inactive)<ref name= ''Hall''>PMID:12213964</ref>. Increasing the rate of Ras inactivation decreases cell proliferation linked to cancer<ref name= ''Cimino''>PMID:29478615</ref>. | ||
