Sandbox Reserved 1724: Difference between revisions

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==== Warfarin Dependence on Catalytic Cysteines ====

The anticoagulant [https://en.wikipedia.org/wiki/Warfarin warfarin] works by inhibiting VKOR (See "Medical Relevance"). Warfarin binding also depends on the catalytic cysteines. Warfarin is able to bind to the fully oxidized open form of VKOR as shown in <scene name='90/904329/Cat_cycle_step1_warf/2'>step I</scene> of the catalytic cycle. Once Warfarin binds, VKOR is considered to be in a closed conformation since the substrate cannot enter, despite the lack of disulfide bridge changes. Warfarin can also bind to the partially oxidized form of VKOR as shown in <scene name='90/904329/~~Cat_cycle_2~~/1'>step II</scene> of the catalytic cycle.

The anticoagulant [https://en.wikipedia.org/wiki/Warfarin warfarin] works by inhibiting VKOR (See "Medical Relevance"). Warfarin binding also depends on the catalytic cysteines. Warfarin is able to bind to the fully oxidized open form of VKOR as shown in <scene name='90/904329/Cat_cycle_step1_warf/2'>step I</scene> of the catalytic cycle. Once Warfarin binds, VKOR is considered to be in a closed conformation since the substrate cannot enter, despite the lack of disulfide bridge changes. Warfarin can also bind to the partially oxidized form of VKOR as shown in <scene name='90/904329/Cat_cycle_step2_warf/1'>step II</scene> of the catalytic cycle.

===Superwarfarins===

Sandbox Reserved 1724: Difference between revisions

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 ==== Warfarin Dependence on Catalytic Cysteines ====
-The anticoagulant [https://en.wikipedia.org/wiki/Warfarin warfarin] works by inhibiting VKOR (See "Medical Relevance"). Warfarin binding also depends on the catalytic cysteines. Warfarin is able to bind to the fully oxidized open form of VKOR as shown in <scene name='90/904329/Cat_cycle_step1_warf/2'>step I</scene> of the catalytic cycle. Once Warfarin binds, VKOR is considered to be in a closed conformation since the substrate cannot enter, despite the lack of disulfide bridge changes. Warfarin can also bind to the partially oxidized form of VKOR as shown in <scene name='90/904329/Cat_cycle_2/1'>step II</scene> of the catalytic cycle.
+The anticoagulant [https://en.wikipedia.org/wiki/Warfarin warfarin] works by inhibiting VKOR (See "Medical Relevance"). Warfarin binding also depends on the catalytic cysteines. Warfarin is able to bind to the fully oxidized open form of VKOR as shown in <scene name='90/904329/Cat_cycle_step1_warf/2'>step I</scene> of the catalytic cycle. Once Warfarin binds, VKOR is considered to be in a closed conformation since the substrate cannot enter, despite the lack of disulfide bridge changes. Warfarin can also bind to the partially oxidized form of VKOR as shown in <scene name='90/904329/Cat_cycle_step2_warf/1'>step II</scene> of the catalytic cycle.
 ===Superwarfarins===