Sandbox Reserved 1700: Difference between revisions
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=== Ligands === | === Ligands === | ||
[[Image:Endogenous_ligands.png|400px|right|thumb|'''Figure 6.''' Endogenous MRGPRX2 ligands with positive regions in blue and hydrophobic regions in green. C48/80 and LL-37 are both released by the body as an allergic reaction response<ref name= "Dondalska">PMID: 33101278</ref>. These compounds can bind to MRGPRX2 and activate it, explaining how itching is a side effect of allergic reactions.]] | [[Image:Endogenous_ligands.png|400px|right|thumb|'''Figure 6.''' Endogenous MRGPRX2 ligands with positive regions in blue and hydrophobic regions in green. C48/80 and LL-37 are both released by the body as an allergic reaction response<ref name= "Dondalska">PMID: 33101278</ref>. These compounds can bind to MRGPRX2 and activate it, explaining how itching is a side effect of allergic reactions.]] | ||
[[Image:Agonists - Copy.png|400px| | [[Image:Agonists - Copy.png|400px|left|thumb|'''Figure 7.''' Agonists of MRGPRX2 due to their structural similarities to known ligands. Positive regions shown in blue and hydrophobic regions in green. Cortistatin-14, PAMP-12, and Zinc-3573 are all known to bind to MRGPRX2 with high affinity, and inhibit mast cell degranulation<ref name="Yang">PMID: 34789875</ref><ref name="Cao">PMID: 34789874</ref>]] | ||
MRGPRX2 binds a wide range of small molecule and peptide ligands. These ligands have positively charged regions which can interact with the negative binding pocket, sub-pocket 1. Some of these larger ligands also have a hydrophobic region which can interact with sub-pocket 2. MRGPRX2 is activated by [https://pubchem.ncbi.nlm.nih.gov/compound/118797323 C48/80]<ref name="Yang">PMID: 34789875</ref><ref name="Cao">PMID: 34789874</ref> and LL-37 <ref name= "Dondalska" />, among other endogenous inflammatory chemicals. | MRGPRX2 binds a wide range of small molecule and peptide ligands. These ligands have positively charged regions which can interact with the negative binding pocket, sub-pocket 1. Some of these larger ligands also have a hydrophobic region which can interact with sub-pocket 2. MRGPRX2 is activated by [https://pubchem.ncbi.nlm.nih.gov/compound/118797323 C48/80]<ref name="Yang">PMID: 34789875</ref><ref name="Cao">PMID: 34789874</ref> and LL-37 <ref name= "Dondalska" />, among other endogenous inflammatory chemicals. | ||
