Sandbox Reserved 1700: Difference between revisions

[[Image:Endogenous_ligands.png|400px|right|thumb|'''Figure 6.''' Endogenous MRGPRX2 ligands with positive regions in blue and hydrophobic regions in green. C48/80 and LL-37 are both released by the body as an allergic reaction response<ref name= "Dondalska">PMID: 33101278</ref>. These compounds can bind to MRGPRX2 and activate it, explaining how itching is a side effect of allergic reactions.]]

MRGPRX2 binds a wide range of small molecule and peptide ligands. These ligands have positively charged regions which can interact with the negative binding pocket, sub-pocket 1. Some of these larger ligands also have a hydrophobic region which can interact with sub-pocket 2. MRGPRX2 is activated by [https://pubchem.ncbi.nlm.nih.gov/compound/118797323 C48/80]<ref name="Yang">PMID: 34789875</ref><ref name="Cao">PMID: 34789874</ref> and LL-37 <ref name= "Dondalska" />, among other endogenous inflammatory chemicals.

Other endogenous compounds that share similar characteristics of these ligands are [https://pubchem.ncbi.nlm.nih.gov/compound/95882507 Zinc-3573], [https://pubchem.ncbi.nlm.nih.gov/compound/PAMP-12-_human_-porcine#section=Structures PAMP-12], and [https://pubchem.ncbi.nlm.nih.gov/compound/44208884 Cortistatin-14]. These molecules are known agonists of MRGPRX2 and bind similarly to sub-pockets 1 and 2.  

An endogenous peptide, <scene name='90/904306/C-14_in_site/4'>Cortistatin-14</scene> models these interactions, binding to sub-pocket 1 through LYS-3 and sub-pocket 2 through hydrophobic interactions.