Sandbox Reserved 1700: Difference between revisions

Line 124:

[[Image:Agonists - Copy.png|400px|~~left~~|thumb|'''Figure 7.''' Agonists of MRGPRX2 due to their structural similarities to known ligands. Positive regions shown in blue and hydrophobic regions in green. Cortistatin-14, PAMP-12, and Zinc-3573 are all known to bind to MRGPRX2 with high affinity, and inhibit mast cell degranulation<ref name="Yang">PMID: 34789875</ref><ref name="Cao">PMID: 34789874</ref>]]

[[Image:Agonists - Copy.png|400px|right|thumb|'''Figure 7.''' Agonists of MRGPRX2 due to their structural similarities to known ligands. Positive regions shown in blue and hydrophobic regions in green. Cortistatin-14, PAMP-12, and Zinc-3573 are all known to bind to MRGPRX2 with high affinity, and inhibit mast cell degranulation<ref name="Yang">PMID: 34789875</ref><ref name="Cao">PMID: 34789874</ref>]]

Other endogenous compounds that share similar characteristics of these ligands are [https://pubchem.ncbi.nlm.nih.gov/compound/95882507 Zinc-3573], [https://pubchem.ncbi.nlm.nih.gov/compound/PAMP-12-_human_-porcine#section=Structures PAMP-12], and [https://pubchem.ncbi.nlm.nih.gov/compound/44208884 Cortistatin-14]. These molecules are known agonists of MRGPRX2 and bind similarly to sub-pockets 1 and 2.

An endogenous peptide, <scene name='90/904306/C-14_in_site/4'>Cortistatin-14</scene> models these interactions, binding to sub-pocket 1 through LYS-3 and sub-pocket 2 through hydrophobic interactions.

Sandbox Reserved 1700: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 124: / Line 124: @@
-[[Image:Agonists - Copy.png|400px|left|thumb|'''Figure 7.''' Agonists of MRGPRX2 due to their structural similarities to known ligands. Positive regions shown in blue and hydrophobic regions in green. Cortistatin-14, PAMP-12, and Zinc-3573 are all known to bind to MRGPRX2 with high affinity, and inhibit mast cell degranulation<ref name="Yang">PMID: 34789875</ref><ref name="Cao">PMID: 34789874</ref>]]
+[[Image:Agonists - Copy.png|400px|right|thumb|'''Figure 7.''' Agonists of MRGPRX2 due to their structural similarities to known ligands. Positive regions shown in blue and hydrophobic regions in green. Cortistatin-14, PAMP-12, and Zinc-3573 are all known to bind to MRGPRX2 with high affinity, and inhibit mast cell degranulation<ref name="Yang">PMID: 34789875</ref><ref name="Cao">PMID: 34789874</ref>]]
 Other endogenous compounds that share similar characteristics of these ligands are [https://pubchem.ncbi.nlm.nih.gov/compound/95882507 Zinc-3573], [https://pubchem.ncbi.nlm.nih.gov/compound/PAMP-12-_human_-porcine#section=Structures PAMP-12], and [https://pubchem.ncbi.nlm.nih.gov/compound/44208884 Cortistatin-14]. These molecules are known agonists of MRGPRX2 and bind similarly to sub-pockets 1 and 2.
 An endogenous peptide, <scene name='90/904306/C-14_in_site/4'>Cortistatin-14</scene> models these interactions, binding to sub-pocket 1 through LYS-3 and sub-pocket 2 through hydrophobic interactions.