Sandbox Reserved 1700: Difference between revisions
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Other drugs that have been known to trigger allergic reactions and even anaphylactic responses are opioids [https://pubchem.ncbi.nlm.nih.gov/compound/Morphine morphine] or [https://pubchem.ncbi.nlm.nih.gov/compound/5284371 codeine]<ref name= "Cao" />, which could explain anaphylactic responses to anesthetics seen in some patients<ref name="McNeil" />. Upon analysis of these drugs, they share many structural similarities that are known to bind to the sub-pockets in MRGPRX2, shown in '''Figure 9''', which is a possible explanation for the unwanted itch and inflammation responses produced in some patients when administering these drugs <ref name="McNeil" /><ref name= "Cao" />. | Other drugs that have been known to trigger allergic reactions and even anaphylactic responses are opioids [https://pubchem.ncbi.nlm.nih.gov/compound/Morphine morphine] or [https://pubchem.ncbi.nlm.nih.gov/compound/5284371 codeine]<ref name= "Cao" />, which could explain anaphylactic responses to anesthetics seen in some patients<ref name="McNeil" />. Upon analysis of these drugs, they share many structural similarities that are known to bind to the sub-pockets in MRGPRX2, shown in '''Figure 9''', which is a possible explanation for the unwanted itch and inflammation responses produced in some patients when administering these drugs <ref name="McNeil" /><ref name= "Cao" />. | ||
Possible treatments for these unwanted side effects of drugs can be developed by understanding the mechanism of the MRGPRX2 receptor. Research on Cortistatin-14, an endogenous neuropeptide, has shown that it has antiinflammatory properties because of how it binds to the MRGPRX2 receptor <ref name= "Gonzalez-Rey">PMID: 16492802</ref>. Additionally, Osthole, an extract from Cnidium monnieri plants, also known as Monnier's snowparsley, demonstrates similar MRGPRX2 inhibition because of its structural similarity to many known ligands for this receptor, and could possibly be used as a treatment option for adverse allergic reactions to commonly prescribed drugs (donstralta). More research on MRGPRX2 can open the door for the development of drugs that avoid activation of the MRGPRX2 receptor, or possible treatments for excessive inflammation and allergic reactions. | Possible treatments for these unwanted side effects of drugs can be developed by understanding the mechanism of the MRGPRX2 receptor. Research on Cortistatin-14, an endogenous neuropeptide, has shown that it has antiinflammatory properties because of how it binds to the MRGPRX2 receptor <ref name= "Gonzalez-Rey">PMID: 16492802</ref>. Additionally, [https://pubchem.ncbi.nlm.nih.gov/compound/Osthole Osthole], an extract from[https://en.wikipedia.org/wiki/Cnidium_monnieri Cnidium monnieri plants], also known as Monnier's snowparsley, demonstrates similar MRGPRX2 inhibition because of its structural similarity to many known ligands for this receptor, and could possibly be used as a treatment option for adverse allergic reactions to commonly prescribed drugs (donstralta). More research on MRGPRX2 can open the door for the development of drugs that avoid activation of the MRGPRX2 receptor, or possible treatments for excessive inflammation and allergic reactions. | ||
[[Image:Screen Shot 2022-03-29 at 10.48.36 AM.png|500px|center|thumb|'''Figure 10.'''Schematic representation of MRGPRX2 triggering a cellular response and inflammation.]] | |||
[[Image:Screen Shot 2022-03-29 at 10.48.36 AM.png|500px|center|thumb|Schematic representation of cellular response]] | |||
== 3D Structures == | == 3D Structures == | ||
