Neurofibromin: Difference between revisions
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==Downstream Effects== | ==Downstream Effects== | ||
Misregulated [https://proteopedia.org/wiki/index.php/GTPase_HRas Ras activity] can lead to uncontrolled signaling in many different cell signaling pathways. Figure 2 provides an overview of the pathways that are connected to Ras. As shown, neurofibromin's ability to regulate Ras activity can alter cell proliferation signaling, activation/ inactivation of transcription factors, and cell apoptotic factors, making its proper functioning crucial <ref name= ''McCubrey''>PMID:17126425</ref>. Additionally, due to its overall importance in multiple cell pathways, neither neurofibromin nor Ras profile as possible drug targets. | Misregulated [https://proteopedia.org/wiki/index.php/GTPase_HRas Ras activity] can lead to uncontrolled signaling in many different cell signaling pathways. Figure 2 provides an overview of the pathways that are connected to Ras. As shown, neurofibromin's ability to regulate Ras activity can alter cell proliferation signaling, activation/ inactivation of transcription factors, and cell apoptotic factors, making its proper functioning crucial <ref name= ''McCubrey''>PMID:17126425</ref>. Additionally, due to its overall importance in multiple cell pathways, neither neurofibromin nor Ras profile as possible drug targets. | ||
[[Image:signaling_pathway_for_ras.jpg|600 px|thumb|Figure 3: Downstream proliferation of Ras signals have a variety of impacts, including gene regulation, cell proliferation, and cell growth; By cybertory - This file was derived from: Signal transduction v1.png, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=12081090]] | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
