Sandbox Reserved 1706: Difference between revisions
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Mutations to NF1 in the critical interaction involved in the GRD active site with R1276, structurally and functionally prove why they can cause cancer, as Ras is no longer mediated. The importance of this residue when binding to Ras may be able to contribute to future studies in potentially mimicking this arginine finger when bound to Ras, in cases where mutations would impact R1276 in its normal function. Observing the nature of NF1 can further drug development and further improve what is already known about NF1.<ref name="Bergoug"> DOI:10.3390/cells9112365</ref><ref name="Kioro"> DOI:10.1038/labinvest.2016.142</ref><ref name="Sabatini"> DOI:10.1007/s11940-015-0355-4</ref> | Mutations to NF1 in the critical interaction involved in the GRD active site with R1276, structurally and functionally prove why they can cause cancer, as Ras is no longer mediated. The importance of this residue when binding to Ras may be able to contribute to future studies in potentially mimicking this arginine finger when bound to Ras, in cases where mutations would impact R1276 in its normal function. Observing the nature of NF1 can further drug development and further improve what is already known about NF1.<ref name="Bergoug"> DOI:10.3390/cells9112365</ref><ref name="Kioro"> DOI:10.1038/labinvest.2016.142</ref><ref name="Sabatini"> DOI:10.1007/s11940-015-0355-4</ref> | ||
==FINAL SCENES COPY AND PASTE== | ==FINAL SCENES COPY AND PASTE== | ||
Open/Closed Conformation Scenes | |||
Open- | |||
<scene name='90/904311/Open_conformation/11'>Open_Conformation(dimer)</scene> | |||
Closed- | |||
<scene name='90/904311/Closed_conformation/6'>Closed_Conformation(dimer)</scene> | |||
Domain Scenes- | Domain Scenes- | ||
<scene name='90/904311/Domainintro_open/ | <scene name='90/904311/Domainintro_open/10'>Open conformation monomomer(paste at top of domain section)</scene> | ||
<scene name='90/904311/N-heatarm_open/2'>N-HEATARM(place in heat section)</scene> | <scene name='90/904311/N-heatarm_open/2'>N-HEATARM(place in heat section)</scene> | ||
