Sandbox Reserved 1709: Difference between revisions

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=== Mutations ===
=== Mutations ===
Some key <scene name='90/906893/Active_site_mutations/2'>mutations</scene> that can be detrimental to the VKOR structure are mutations of the <scene name='90/906893/Active_site/4'>binding pocket</scene>. The two main residues, N80 and Y139, can be mutated to A80 and F139 creating a decrease in recognition and stabilization.
Within the <scene name='90/906893/Active_site/4'>binding pocket</scene> mutations of the <scene name='90/904314/Active_site/1'>active site residues</scene> can occur. These mutations can be detrimental to the VKOR structure and function. Two of the most common mutations occur to residues N80 and Y139 mutating them to <scene name='90/904314/Active_site_mutations/1'>A80 and F139</scene>. The change in polarity of these mutations from polar to nonpolar will cause a decrease in recognition and stabilization due to the inability to provide hydrogen bonds.
 




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