Sandbox Reserved 1725: Difference between revisions

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===Superwarfarins===

[[Image:VKOR_Substrates.jpg|300 px|left|thumb|'''Figure 4. Vitamin K, Warfarin, and Brodifacoum''' Above is a comparison of the 2D structures of VKOR's natural substrate, the blood thinner warfarin, and the superwarfarin brodifacoum.]]

More potent warfarin derivatives, called [https://en.wikipedia.org/wiki/Superwarfarin superwarfarins], are used as rodenticides. The duration of one superwarfarin, [https://en.wikipedia.org/wiki/Brodifacoum brodifacoum], has been reported as 15-30 days <ref name="Chong">PMID:31857739</ref> vs. the clinical warfarin duration of 2-5 days<ref name="Patel">PMID:29261922</ref>. Superwarfarins have bulkier side chains that allow them to stay bound to VKOR for long periods of time, causing prolonged and uncontrolled bleeding<ref name="Chong">PMID:31857739</ref>. The enhanced binding is due to interactions between the bulky side chains and the hydrophobic residues of VKOR's binding pocket, as shown in brodifacoum.

More potent warfarin derivatives, called [https://en.wikipedia.org/wiki/Superwarfarin superwarfarins], are used as rodenticides. The duration of one superwarfarin, [https://en.wikipedia.org/wiki/Brodifacoum brodifacoum], has been reported as 15-30 days <ref name="Chong">PMID:31857739</ref> vs. the clinical warfarin duration of 2-5 days<ref name="Patel">PMID:29261922</ref>. Superwarfarins have bulkier side chains that allow them to stay bound to VKOR for long periods of time, causing prolonged and uncontrolled bleeding<ref name="Chong">PMID:31857739</ref>. The <scene name='90/904330/Brodifacoum3/1'>enhanced binding</scene> is due to interactions between the bulky side chains and the hydrophobic residues of VKOR's binding pocket, as shown in brodifacoum.

</StructureSection>

Sandbox Reserved 1725: Difference between revisions

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@@ Line 43: / Line 43: @@
 ===Superwarfarins===
 [[Image:VKOR_Substrates.jpg|300 px|left|thumb|'''Figure 4. Vitamin K, Warfarin, and Brodifacoum''' Above is a comparison of the 2D structures of VKOR's natural substrate, the blood thinner warfarin, and the superwarfarin brodifacoum.]]
-More potent warfarin derivatives, called [https://en.wikipedia.org/wiki/Superwarfarin superwarfarins], are used as rodenticides. The duration of one superwarfarin, [https://en.wikipedia.org/wiki/Brodifacoum brodifacoum], has been reported as 15-30 days <ref name="Chong">PMID:31857739</ref> vs. the clinical warfarin duration of 2-5 days<ref name="Patel">PMID:29261922</ref>. Superwarfarins have bulkier side chains that allow them to stay bound to VKOR for long periods of time, causing prolonged and uncontrolled bleeding<ref name="Chong">PMID:31857739</ref>. The enhanced binding is due to interactions between the bulky side chains and the hydrophobic residues of VKOR's binding pocket, as shown in brodifacoum.
+More potent warfarin derivatives, called [https://en.wikipedia.org/wiki/Superwarfarin superwarfarins], are used as rodenticides. The duration of one superwarfarin, [https://en.wikipedia.org/wiki/Brodifacoum brodifacoum], has been reported as 15-30 days <ref name="Chong">PMID:31857739</ref> vs. the clinical warfarin duration of 2-5 days<ref name="Patel">PMID:29261922</ref>. Superwarfarins have bulkier side chains that allow them to stay bound to VKOR for long periods of time, causing prolonged and uncontrolled bleeding<ref name="Chong">PMID:31857739</ref>. The <scene name='90/904330/Brodifacoum3/1'>enhanced binding</scene> is due to interactions between the bulky side chains and the hydrophobic residues of VKOR's binding pocket, as shown in brodifacoum.
 </StructureSection>