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Other drugs that have been known to trigger allergic reactions and even anaphylactic responses are opioids [https://pubchem.ncbi.nlm.nih.gov/compound/Morphine morphine] or [https://pubchem.ncbi.nlm.nih.gov/compound/5284371 codeine]<ref name= "Cao" />, which could explain anaphylactic responses to anesthetics seen in some patients<ref name="McNeil" />. Upon analysis of these drugs, they share many structural similarities that are known to bind to the sub-pockets in MRGPRX2, shown in '''Figure 9''', which is a possible explanation for the unwanted itch and inflammation responses produced in some patients when administering these drugs <ref name="McNeil" /><ref name= "Cao" />.

Possible treatments for these unwanted side effects of drugs can be developed by understanding the mechanism of the MRGPRX2 receptor. Research on Cortistatin-14, an endogenous neuropeptide, has shown that it has ~~antiinflammatory~~ properties because of how it binds to the MRGPRX2 receptor <ref name= "Gonzalez-Rey">PMID: 16492802</ref>. Additionally, [https://pubchem.ncbi.nlm.nih.gov/compound/Osthole Osthole], an extract from [https://en.wikipedia.org/wiki/Cnidium_monnieri Cnidium monnieri plants], also known as Monnier's ~~snowparsley~~, demonstrates similar MRGPRX2 inhibition because of its structural similarity to many known ligands for this receptor, and could possibly be used as a treatment option for adverse allergic reactions to commonly prescribed drugs<ref name= "Dondalska" />. More research on MRGPRX2 can open the door for the development of drugs that avoid activation of the MRGPRX2 receptor, or possible treatments for excessive inflammation and allergic reactions.

Possible treatments for these unwanted side effects of drugs can be developed by understanding the mechanism of the MRGPRX2 receptor. Research on Cortistatin-14, an endogenous neuropeptide ('''Figure 7'''), has shown that it has anti-inflammatory properties because of how it binds to the MRGPRX2 receptor <ref name= "Gonzalez-Rey">PMID: 16492802</ref>. Additionally, [https://pubchem.ncbi.nlm.nih.gov/compound/Osthole Osthole], an extract from [https://en.wikipedia.org/wiki/Cnidium_monnieri Cnidium monnieri plants], also known as Monnier's snow parsley, demonstrates similar MRGPRX2 inhibition because of its structural similarity to many known ligands for this receptor, and could possibly be used as a treatment option for adverse allergic reactions to commonly prescribed drugs<ref name= "Dondalska" />. More research on MRGPRX2 can open the door for the development of drugs that avoid activation of the MRGPRX2 receptor, or possible treatments for excessive inflammation and allergic reactions.

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Revision as of 19:46, 18 April 2022 view source Alexandra L. Carmichael (talk \| contribs) 222 edits No edit summary ← Older edit		Revision as of 19:47, 18 April 2022 view source Alexandra L. Carmichael (talk \| contribs) 222 edits No edit summary Newer edit →
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	Other drugs that have been known to trigger allergic reactions and even anaphylactic responses are opioids [https://pubchem.ncbi.nlm.nih.gov/compound/Morphine morphine] or [https://pubchem.ncbi.nlm.nih.gov/compound/5284371 codeine]<ref name= "Cao" />, which could explain anaphylactic responses to anesthetics seen in some patients<ref name="McNeil" />. Upon analysis of these drugs, they share many structural similarities that are known to bind to the sub-pockets in MRGPRX2, shown in '''Figure 9''', which is a possible explanation for the unwanted itch and inflammation responses produced in some patients when administering these drugs <ref name="McNeil" /><ref name= "Cao" />.		Other drugs that have been known to trigger allergic reactions and even anaphylactic responses are opioids [https://pubchem.ncbi.nlm.nih.gov/compound/Morphine morphine] or [https://pubchem.ncbi.nlm.nih.gov/compound/5284371 codeine]<ref name= "Cao" />, which could explain anaphylactic responses to anesthetics seen in some patients<ref name="McNeil" />. Upon analysis of these drugs, they share many structural similarities that are known to bind to the sub-pockets in MRGPRX2, shown in '''Figure 9''', which is a possible explanation for the unwanted itch and inflammation responses produced in some patients when administering these drugs <ref name="McNeil" /><ref name= "Cao" />.

	Possible treatments for these unwanted side effects of drugs can be developed by understanding the mechanism of the MRGPRX2 receptor. Research on Cortistatin-14, an endogenous neuropeptide, has shown that it has ~~antiinflammatory~~ properties because of how it binds to the MRGPRX2 receptor <ref name= "Gonzalez-Rey">PMID: 16492802</ref>. Additionally, [https://pubchem.ncbi.nlm.nih.gov/compound/Osthole Osthole], an extract from [https://en.wikipedia.org/wiki/Cnidium_monnieri Cnidium monnieri plants], also known as Monnier's ~~snowparsley~~, demonstrates similar MRGPRX2 inhibition because of its structural similarity to many known ligands for this receptor, and could possibly be used as a treatment option for adverse allergic reactions to commonly prescribed drugs<ref name= "Dondalska" />. More research on MRGPRX2 can open the door for the development of drugs that avoid activation of the MRGPRX2 receptor, or possible treatments for excessive inflammation and allergic reactions.		Possible treatments for these unwanted side effects of drugs can be developed by understanding the mechanism of the MRGPRX2 receptor. Research on Cortistatin-14, an endogenous neuropeptide ('''Figure 7'''), has shown that it has anti-inflammatory properties because of how it binds to the MRGPRX2 receptor <ref name= "Gonzalez-Rey">PMID: 16492802</ref>. Additionally, [https://pubchem.ncbi.nlm.nih.gov/compound/Osthole Osthole], an extract from [https://en.wikipedia.org/wiki/Cnidium_monnieri Cnidium monnieri plants], also known as Monnier's snow parsley, demonstrates similar MRGPRX2 inhibition because of its structural similarity to many known ligands for this receptor, and could possibly be used as a treatment option for adverse allergic reactions to commonly prescribed drugs<ref name= "Dondalska" />. More research on MRGPRX2 can open the door for the development of drugs that avoid activation of the MRGPRX2 receptor, or possible treatments for excessive inflammation and allergic reactions.