Sandbox Reserved 1725: Difference between revisions
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=== Active Site === | === Active Site === | ||
VKOR uses two substrate binding amino acids, <scene name='90/904329/Kohhbond/4'>Tyr139 and Asn80</scene> to stabilize vitamin K in the binding pocket. Tyr139 and Asn80 hydrogen bond to carbonyl groups on vitamin K and | VKOR uses two substrate-binding amino acids, <scene name='90/904329/Kohhbond/4'>Tyr139 and Asn80</scene> to stabilize vitamin K in the binding pocket. Tyr139 and Asn80 hydrogen bond to carbonyl groups on vitamin K and stabilize it within the binding pocket <ref name="Liu">PMID:33154105</ref>. Vitamin K is also bound via hydrophobic interactions within the binding pocket of VKOR. Hydrophobic residues of VKOR, such as <scene name='90/904329/Kohydroaa/5'>Phe83, Phe87, Tyr88</scene>, form a hydrophobic tunnel within the binding pocket <ref name="Liu">PMID:33154105</ref>. | ||
== Catalytic Cycle == | == Catalytic Cycle == | ||
