Sandbox Reserved 1701: Difference between revisions
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== Function == | == Function == | ||
[[Image:Screen Shot 2022-04-162 at 2.49.26 PM.png|420px|right|thumb|'''Figure 11.'''Schematic representation of cellular response]] | |||
GPCRs undergo a conformational change in their 7TMD region upon ligand binding. This signal is then transduced to the G-protein allowing for downstream responses due to <scene name='90/904306/Interface_2/1'>interactions</scene> between the alpha subunit of the G-protein and the transmembrane protein which activates g-protein by GTP exchange. | GPCRs undergo a conformational change in their 7TMD region upon ligand binding. This signal is then transduced to the G-protein allowing for downstream responses due to <scene name='90/904306/Interface_2/1'>interactions</scene> between the alpha subunit of the G-protein and the transmembrane protein which activates g-protein by GTP exchange. | ||
=== Before Activation === | === Before Activation === | ||
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=== Clinical Relevance === | === Clinical Relevance === | ||
