Sandbox Reserved 1709: Difference between revisions

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==Catalytic Mechanism of VKOR==

=== Brief Overview ===

The overall mechanism works to convert Vitamin K epoxide to an activated form of Vitamin K hydroquinone, as noted in Figure 1. The substrate will bind VKOR at the binding pocket in the <scene name='90/~~906893~~/Open_conformation/1'>open conformation</scene> and induce the <scene name='90/~~906893~~/Closed_conformation/4'>closed conformation</scene>. Transition from open to closed conformation occurs with the oxidation of the C43-C51 disulfide bridge. Here, VKOR will utilize the second pair of <scene name='90/904314/Disulfide_bridge_stabilization/7'>catalytic cysteines</scene>, C132 and C135, to reduce KO into Vitamin K and Vitamin K into KH2. KH2 will be released from the binding fully activated and ready for use in the body. VKOR will reset, returning to the open conformation again, prepared for another substrate to bind.

The overall mechanism works to convert Vitamin K epoxide to an activated form of Vitamin K hydroquinone, as noted in Figure 1. The substrate will bind VKOR at the binding pocket in the <scene name='90/904314/Open_conformation/2'>open conformation</scene> and induce the <scene name='90/904314/Closed_conformation/5'>closed conformation</scene>. Transition from open to closed conformation occurs with the oxidation of the C43-C51 disulfide bridge. Here, VKOR will utilize the second pair of <scene name='90/904314/Disulfide_bridge_stabilization/7'>catalytic cysteines</scene>, C132 and C135, to reduce KO into Vitamin K and Vitamin K into KH2. KH2 will be released from the binding fully activated and ready for use in the body. VKOR will reset, returning to the open conformation again, prepared for another substrate to bind.

=== Enzymatic Mechanism ===

Sandbox Reserved 1709: Difference between revisions

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@@ Line 24: / Line 24: @@
 ==Catalytic Mechanism of VKOR==
 === Brief Overview ===
-The overall mechanism works to convert Vitamin K epoxide to an activated form of Vitamin K hydroquinone, as noted in Figure 1. The substrate will bind VKOR at the binding pocket in the <scene name='90/906893/Open_conformation/1'>open conformation</scene> and induce the <scene name='90/906893/Closed_conformation/4'>closed conformation</scene>. Transition from open to closed conformation occurs with the oxidation of the C43-C51 disulfide bridge. Here, VKOR will utilize the second pair of <scene name='90/904314/Disulfide_bridge_stabilization/7'>catalytic cysteines</scene>, C132 and C135, to reduce KO into Vitamin K and Vitamin K into KH2. KH2 will be released from the binding fully activated and ready for use in the body. VKOR will reset, returning to the open conformation again, prepared for another substrate to bind.
+The overall mechanism works to convert Vitamin K epoxide to an activated form of Vitamin K hydroquinone, as noted in Figure 1. The substrate will bind VKOR at the binding pocket in the <scene name='90/904314/Open_conformation/2'>open conformation</scene> and induce the <scene name='90/904314/Closed_conformation/5'>closed conformation</scene>. Transition from open to closed conformation occurs with the oxidation of the C43-C51 disulfide bridge. Here, VKOR will utilize the second pair of <scene name='90/904314/Disulfide_bridge_stabilization/7'>catalytic cysteines</scene>, C132 and C135, to reduce KO into Vitamin K and Vitamin K into KH2. KH2 will be released from the binding fully activated and ready for use in the body. VKOR will reset, returning to the open conformation again, prepared for another substrate to bind.
 === Enzymatic Mechanism ===