Sandbox Reserved 1701: Difference between revisions

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=====CWxP Motif=====
=====CWxP Motif=====
The <scene name='90/904306/Cpxw_motif_2/2'>CWxP motif</scene> is almost fully conserved except for Trp-236, or the toggle switch, which is replaced with Gly-236. Cys-235, Leu-237, and Pro-238 are all conserved. CYS6.47 may play a fundamental role in GPCR activity by participating in the rearrangement of TM6 and TM7 upon receptor activation<ref name="Olivella>PMID:23497259</ref>. This residue's role is supported by its conservation in MRGPRX2 as it is a functional GPCR.
The <scene name='90/904306/Cpxw_motif_2/2'>CWxP motif</scene> is almost fully conserved except for Trp-236, or the toggle switch, which is replaced with Gly-236. Cys-235, Leu-237, and Pro-238 are all conserved. Cys6.47 may play a fundamental role in GPCR activity by participating in the rearrangement of TM6 and TM7 upon receptor activation<ref name="Olivella>PMID:23497259</ref>. This residue's role is supported by its conservation in MRGPRX2 as it is a functional GPCR.


=== Ligands ===
=== Ligands ===
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