Sandbox Reserved 1701: Difference between revisions

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=== Clinical Relevance ===
== Clinical Relevance ==
[[Image:Activating_drugs.png |400px|right|thumb|'''Figure 10.''' Common prescriptions that are tied to adverse itching side effects include nateglinide, morphine, and codeine. These drugs have structural similarities to known ligands for the MRGPRX2 receptor, and can lead to MRGPRX2 activation.]]
[[Image:Activating_drugs.png |400px|right|thumb|'''Figure 10.''' Common prescriptions that are tied to adverse itching side effects include nateglinide, morphine, and codeine. These drugs have structural similarities to known ligands for the MRGPRX2 receptor, and can lead to MRGPRX2 activation.]]
Many medications commonly list chronic skin itching or inflammatory responses as side effects, such as [https://pubchem.ncbi.nlm.nih.gov/compound/Nateglinide nateglinide], an anti-diabetic drug <ref name= "Cao" />. Other prescribed medications that list itching as a possible side effect are [https://pubchem.ncbi.nlm.nih.gov/compound/Atracurium#section=2D-Structure Atracurium], [https://pubchem.ncbi.nlm.nih.gov/compound/441290 Rocuronium], [https://pubchem.ncbi.nlm.nih.gov/compound/2764 Ciprofloxacin], and [https://pubchem.ncbi.nlm.nih.gov/compound/149096 Levofloxacin]<ref name="Navines-Ferrer">PMID:30072729</ref>, all of which are tied to MRGPRX2 activation.  
Many medications commonly list chronic skin itching or inflammatory responses as side effects, such as [https://pubchem.ncbi.nlm.nih.gov/compound/Nateglinide nateglinide], an anti-diabetic drug <ref name= "Cao" />. Other prescribed medications that list itching as a possible side effect are [https://pubchem.ncbi.nlm.nih.gov/compound/Atracurium#section=2D-Structure Atracurium], [https://pubchem.ncbi.nlm.nih.gov/compound/441290 Rocuronium], [https://pubchem.ncbi.nlm.nih.gov/compound/2764 Ciprofloxacin], and [https://pubchem.ncbi.nlm.nih.gov/compound/149096 Levofloxacin]<ref name="Navines-Ferrer">PMID:30072729</ref>, all of which are tied to MRGPRX2 activation.