Sandbox Reserved 1709: Difference between revisions

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=== Mutations ===
=== Mutations ===
Within the <scene name='90/904314/Active_site/2'>binding pocket</scene> mutations of the <scene name='90/904314/Vkor_with_warfarin_bound/4'>active site residues</scene> can occur. These mutations can be detrimental to the VKOR structure and function<ref>DOI 10.1126/science.abc5667</ref>. Two of the most common mutations occur to residues N80 and Y139 mutating them to <scene name='90/904314/Active_site_mutations/2'>A80 and F139</scene>. The change in polarity of these mutations from polar to nonpolar will cause a decrease in recognition and stabilization due to the inability to provide hydrogen bonds to the bound substrate.  
Within the <scene name='90/904314/Active_site/2'>binding pocket</scene> mutations of the <scene name='90/904314/Vkor_with_warfarin_bound/4'>active site residues</scene> can occur. These mutations can be detrimental to the VKOR structure and function<ref>DOI 10.1126/science.abc5667</ref>. Two of the most common mutations occur to residues N80 and Y139 when they are mutated to <scene name='90/904314/Active_site_mutations/2'>A80 and F139</scene>. The change in polarity of these mutations from polar to nonpolar will cause a decrease in recognition and stabilization due to the inability to provide hydrogen bonds to the bound substrate.  




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