Sandbox Reserved 1715: Difference between revisions
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== Conformational Changes == | == Conformational Changes == | ||
[[Image: | [[Image:Overview_mGlu_2.jpg|900 px|center|thumb|Figure 3. Illustration of mGlu's conformational change process.]] | ||
'''1.''' In its resting state, mGlu is in an <scene name='90/904320/Inactive_mglu/4'>inactive homodimeric form</scene>. In this conformation, the receptor is considered open with an inter-lobe angle of 44°<ref name="Seven">PMID:34194039</ref>. The structure has two free glutamate binding sites in the VFT, the CRDs are separated, and the TMD is not interacting with a G protein<ref name="Seven">PMID:34194039</ref>. | '''1.''' In its resting state, mGlu is in an <scene name='90/904320/Inactive_mglu/4'>inactive homodimeric form</scene>. In this conformation, the receptor is considered open with an inter-lobe angle of 44°<ref name="Seven">PMID:34194039</ref>. The structure has two free glutamate binding sites in the VFT, the CRDs are separated, and the TMD is not interacting with a G protein<ref name="Seven">PMID:34194039</ref>. | ||
