Telomerase: Difference between revisions
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The reverse transcription process begins by the telomerase RNA binding to the 3' end of the overhanging DNA sequence. Once primed, the G-rich sequence (~6-8 nucleotides) polymerizes the end of the DNA. The RNA primer then translocates down the new DNA sequence and polymerizes again. This process repeats until the entire telomere is formed. After one side of the telomere is formed, the telomerase attaches the complementary nucleotide bases to complete the double-stranded telomere at the end of the DNA double helix. | The reverse transcription process begins by the telomerase RNA binding to the 3' end of the overhanging DNA sequence. Once primed, the G-rich sequence (~6-8 nucleotides) polymerizes the end of the DNA. The RNA primer then translocates down the new DNA sequence and polymerizes again. This process repeats until the entire telomere is formed. After one side of the telomere is formed, the telomerase attaches the complementary nucleotide bases to complete the double-stranded telomere at the end of the DNA double helix. | ||
==Telomerase 3D structures== | |||
[[Telomerase 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
==Telomerase 3D structures== | ==Telomerase 3D structures== | ||
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**[[4mnq]] – hTERT + MHC + b-2-microglobulin + T cell receptor<br /> | **[[4mnq]] – hTERT + MHC + b-2-microglobulin + T cell receptor<br /> | ||
**[[5ugw]] – hTERT thumb domain<br /> | **[[5ugw]] – hTERT thumb domain<br /> | ||
**[[7bg9]], [[7bgb]] – hTERT H/ACA RNP lobe – Cryo EM<br /> | |||
**[[7qxa]] – hTERT + TPP1 + DNA – Cryo EM<br /> | |||
**[[7qxb]], [[7qxs]] – hTERT + TPP1 + POT1 + DNA – Cryo EM<br /> | |||
**[[4lmo]] – TERT RNA binding domain - puffer<br /> | **[[4lmo]] – TERT RNA binding domain - puffer<br /> | ||
**[[4o26]] – TERT + telomerase TR – rice fish<br /> | **[[4o26]] – TERT + telomerase TR – rice fish<br /> | ||
**[[ | **[[3du6]], [[3du5]] - rfbTERT catalytic subunit - red flour beetle<br /> | ||
**[[6e53]], [[6uso]], [[6usq]], [[6usp]] - rfbTERT + DNA<br /> | **[[5cqg]] - rfbTERT + inhibitor <br /> | ||
**[[3kyl]], [[6e53]], [[6uso]], [[6usq]], [[6usp]] - rfbTERT + DNA<br /> | |||
**[[7kqm]], [[7kqn]] - rfbTERT telomerase catalytic subunit + DNA + RNA<br /> | |||
**[[6usr]] - rfbTERT + DNA + G2P<br /> | **[[6usr]] - rfbTERT + DNA + G2P<br /> | ||
**[[2b2a]] - TtTERT telomerase catalytic subunit (mutant) - ''Tetrahymena thermophila''<br /> | **[[2b2a]] - TtTERT telomerase catalytic subunit (mutant) - ''Tetrahymena thermophila''<br /> | ||
**[[2r4g]] - TtTERT telomerase catalytic subunit<br /> | **[[2r4g]] - TtTERT telomerase catalytic subunit<br /> | ||
**[[7lma]], [[7lmb]] – TtTERT + telomerase-associated protein + RNA + DNA – Cryo EM<br /> | |||
**[[6d6v]] – TtTERT + telomerase-associated protein + TEB2 + RNA + DNA – Cryo EM<br /> | **[[6d6v]] – TtTERT + telomerase-associated protein + TEB2 + RNA + DNA – Cryo EM<br /> | ||
**[[5c9h]] - TtTERT catalytic subunit + DNA<br /> | **[[5c9h]] - TtTERT catalytic subunit + DNA<br /> | ||
**[[5lgf]] - OgTERT N-terminal - ''Ogataea polymorpha'' - NMR<br /> | **[[5lgf]] - OgTERT N-terminal - ''Ogataea polymorpha'' - NMR<br /> | ||
**[[5npt]] – OgTERT N-terminal <br /> | **[[5npt]] – OgTERT N-terminal <br /> | ||
**[[6zd1]], [[6zd2]], [[6zd6]] - CaTERT – ''Candida albicans''<br /> | |||
**[[6zdp]], [[6zdq]], [[6zdu]] - CaTERT + RNA <br /> | |||
*Telomerase RNA | *Telomerase RNA | ||
**[[7v99]], [[7v9a]] - hTERC in telomerase holoenzyme – Cryo EM<br /> | |||
**[[1q75]], [[2k96]] – hTERC P2b hairpin (mutant) – human – NMR<br /> | **[[1q75]], [[2k96]] – hTERC P2b hairpin (mutant) – human – NMR<br /> | ||
**[[2k95]], [[1na2]] - hTERC P2b hairpin – NMR<br /> | **[[2k95]], [[1na2]] - hTERC P2b hairpin – NMR<br /> | ||
