Sandbox Reserved 1706: Difference between revisions
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==Structure== | ==Structure== | ||
Neurofibromin is a [https://en.wikipedia.org/wiki/Protein_dimer protein dimer] that exists in <scene name='90/904311/Closed_conformation/8'>closed</scene> and <scene name='90/904311/Open_conformation/14'> open</scene> conformations. The exact initiation of structural rearrangement is currently unknown and a point of further research. <ref name="Bourne"> DOI:10.1038/39470</ref><ref name="Lupton"> <ref name="Naschberger"> DOI:10.1038/s41586-021-04024-x</ref>. Both protomers contain 5 separate domains, a N-HEAT ARM, C-HEAT ARM, GRD binding site, GAPex domain, and Sec14-PH domain. | Neurofibromin is a [https://en.wikipedia.org/wiki/Protein_dimer protein dimer] that exists in <scene name='90/904311/Closed_conformation/8'>closed</scene> and <scene name='90/904311/Open_conformation/14'> open</scene> conformations. The exact initiation of structural rearrangement is currently unknown and a point of further research. <ref name="Bourne"> DOI:10.1038/39470</ref><ref name="Lupton"> <ref name="Naschberger"> DOI:10.1038/s41586-021-04024-x</ref>. Both protomers contain 5 separate domains, a N-HEAT/ARM, C-HEAT/ARM, GRD binding site, GAPex domain, and Sec14-PH domain. | ||
===Domains=== | ===Domains=== | ||
