Sandbox Reserved 1717: Difference between revisions

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Warfarin still forms Hydrogen bonds with <scene name='90/904322/Asn80_tyr139_warfarin/1'>Asn80 and Tyr139</scene>. The specific bonds are between Asn80 and the 2-ketone group of warfarin and Tyr139 with the 4-hydroxyl group of warfarin. The rest of the pocket is hydrophobic interactions. The H bonds are necessary for the recognition of the ligand in the binding site of VKOR.

There is a slight difference in the way in which warfarin binds compared to VKO. Warfarin binds are a slightly different angle. This creates a difference in how the cap loop and anchor domain interact, and that noticeable difference is with <scene name='90/904322/Arg58/4'>Arg58</scene>. With VKO, Arg58, located in the cap loop, directly interacts with <scene name='90/904322/Arg58_vko/5'>Glu67</scene> when VKO is bound. When warfarin binds, Arg58 is found inserted between<scene name='90/904322/Arg58_warfarin/2'>Glu67 and His68</scene> of the anchor domain.

There is a slight difference in the way in which warfarin binds compared to VKO. Warfarin binds are a slightly different angle (Fig.7). This creates a difference in how the cap loop and anchor domain interact, and that noticeable difference is with <scene name='90/904322/Arg58/4'>Arg58</scene>. With VKO, Arg58, located in the cap loop, directly interacts with <scene name='90/904322/Arg58_vko/5'>Glu67</scene> when VKO is bound. When warfarin binds, Arg58 is found inserted between<scene name='90/904322/Arg58_warfarin/2'>Glu67 and His68</scene> of the anchor domain.

[[Image:warfarin.jpg|400 px|right|thumb|Figure 6. The slight angle change in which VKO(left) and warfarin(right) bind. The location of the cap domain and how it differs between each is apparent.]]

=== Disease ===

Sandbox Reserved 1717: Difference between revisions

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@@ Line 66: / Line 66: @@
 Warfarin still forms Hydrogen bonds with <scene name='90/904322/Asn80_tyr139_warfarin/1'>Asn80 and Tyr139</scene>. The specific bonds are between Asn80 and the 2-ketone group of warfarin and Tyr139 with the 4-hydroxyl group of warfarin. The rest of the pocket is hydrophobic interactions. The H bonds are necessary for the recognition of the ligand in the binding site of VKOR.
-There is a slight difference in the way in which warfarin binds compared to VKO. Warfarin binds are a slightly different angle. This creates a difference in how the cap loop and anchor domain interact, and that noticeable difference is with <scene name='90/904322/Arg58/4'>Arg58</scene>. With VKO, Arg58, located in the cap loop, directly interacts with <scene name='90/904322/Arg58_vko/5'>Glu67</scene> when VKO is bound. When warfarin binds, Arg58 is found inserted between<scene name='90/904322/Arg58_warfarin/2'>Glu67 and His68</scene> of the anchor domain.
+There is a slight difference in the way in which warfarin binds compared to VKO. Warfarin binds are a slightly different angle (Fig.7). This creates a difference in how the cap loop and anchor domain interact, and that noticeable difference is with <scene name='90/904322/Arg58/4'>Arg58</scene>. With VKO, Arg58, located in the cap loop, directly interacts with <scene name='90/904322/Arg58_vko/5'>Glu67</scene> when VKO is bound. When warfarin binds, Arg58 is found inserted between<scene name='90/904322/Arg58_warfarin/2'>Glu67 and His68</scene> of the anchor domain.
+[[Image:warfarin.jpg|400 px|right|thumb|Figure 6. The slight angle change in which VKO(left) and warfarin(right) bind. The location of the cap domain and how it differs between each is apparent.]]
 === Disease ===