Sandbox Reserved 1719: Difference between revisions
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== Ligand Binding Site == | == Ligand Binding Site == | ||
In <scene name='90/904324/Mrgprx2/5'>MRGPRX2</scene>, the ligand binding pocket is located in the N-terminus of the transmembrane domain and consists of two sub-pockets that differ in physical and chemical properties ('''Figure 2''') that allows for various ligand interactions.<ref name="Can"/><ref name="Yang"/> Unlike most class A GPCRs, the ligand binding site of MRGPRX2 is closer to the surface of the membrane due to the absence and alterations in conserved class A GPCR motifs and structures.<ref name="Can"/><ref name="Yang"/> | In <scene name='90/904324/Mrgprx2/5'>MRGPRX2</scene>, the ligand binding pocket is located in the N-terminus of the transmembrane domain and consists of two sub-pockets that differ in physical and chemical properties ('''Figure 2''') that allows for various ligand interactions.<ref name="Can"/><ref name="Yang"/> Unlike most class A GPCRs, the ligand binding site of MRGPRX2 is closer to the surface of the membrane due to the absence and alterations in conserved class A GPCR motifs and structures.<ref name="Can"/><ref name="Yang"/> | ||
[[Image:Electro_map_with_cortistatin.png|400px|center|thumb|'''Figure 2.''' Electrostatic surface of MRGPRX2 ligand binding pocket with cortistatin-14]] | |||
<jmol> | <jmol> | ||
<jmolButton> | <jmolButton> | ||
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==== Sub-pocket 1 ==== | ==== Sub-pocket 1 ==== | ||
