Sandbox Reserved 1715: Difference between revisions

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== Clinical Relevance ==

Glutamate is a major neurotransmitter in the brain and is known for its role in memory, synaptic plasticity, and neuronal development<ref name="Crupi">PMID:30800054</ref>. Thus, mGlus are located throughout the CNS and play key roles in various neurodegenerative diseases such as [https://en.wikipedia.org/wiki/Alzheimer%27s_disease Alzheimer's Disease] (AD), [https://en.wikipedia.org/wiki/Huntington%27s_disease Huntington's Disease] (HD), [https://en.wikipedia.org/wiki/Parkinson%27s_disease Parkinson’s Disease] (PD), and [https://en.wikipedia.org/wiki/Amyotrophic_lateral_sclerosis Amyotrophic Lateral Sclerosis] (ALS)<ref name="Crupi">PMID:30800054</ref>. Also, due to the key role of glutamate in the brain, mGlus are also being studied for their role in psychiatric disorders like [https://en.wikipedia.org/wiki/Anxiety anxiety] and [https://en.wikipedia.org/wiki/Depression_(mood) depression]<ref name="Crupi">PMID:30800054</ref>. In many of these diseases, the overexpression of glutamate can lead to the overstimulation of mGlus and excitotoxicity <ref name="Bordi">PMID:10416961</ref>. However, an exception to this is the under stimulation of mGlus which can result in schizophrenia<ref name="Conn">PMID:19058862</ref>. Research is ongoing, but studies have proven that agonists, antagonists, PAMs, and NAMs of mGlus are potential treatments for these diseases<ref name="Crupi">PMID:30800054</ref>.

Glutamate is a major neurotransmitter in the brain and is known for its role in memory, synaptic plasticity, and neuronal development<ref name="Crupi">PMID:30800054</ref>. Thus, mGlus are located throughout the CNS and play key roles in various neurodegenerative diseases such as [https://en.wikipedia.org/wiki/Alzheimer%27s_disease Alzheimer's Disease] (AD), [https://en.wikipedia.org/wiki/Huntington%27s_disease Huntington's Disease] (HD), [https://en.wikipedia.org/wiki/Parkinson%27s_disease Parkinson’s Disease] (PD), and [https://en.wikipedia.org/wiki/Amyotrophic_lateral_sclerosis Amyotrophic Lateral Sclerosis] (ALS)<ref name="Crupi">PMID:30800054</ref>. Also, due to the key role of glutamate in the brain, mGlus are also being studied for their role in psychiatric disorders like [https://en.wikipedia.org/wiki/Anxiety anxiety] and [https://en.wikipedia.org/wiki/Depression_(mood) depression]<ref name="Crupi">PMID:30800054</ref>. In many of these diseases, the overexpression of glutamate can lead to the overstimulation of mGlus and excitotoxicity <ref name="Bordi">PMID:10416961</ref>. However, an exception to this is the under stimulation of mGlus which can result in [https://en.wikipedia.org/wiki/Schizophrenia schizophrenia]<ref name="Conn">PMID:19058862</ref>. Research is ongoing, but studies have proven that agonists, antagonists, PAMs, and NAMs of mGlus are potential treatments for these diseases<ref name="Crupi">PMID:30800054</ref>.

== 3D Structures ==

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 == Clinical Relevance ==
-Glutamate is a major neurotransmitter in the brain and is known for its role in memory, synaptic plasticity, and neuronal development<ref name="Crupi">PMID:30800054</ref>. Thus, mGlus are located throughout the CNS and play key roles in various neurodegenerative diseases such as [https://en.wikipedia.org/wiki/Alzheimer%27s_disease Alzheimer's Disease] (AD), [https://en.wikipedia.org/wiki/Huntington%27s_disease Huntington's Disease] (HD), [https://en.wikipedia.org/wiki/Parkinson%27s_disease Parkinson’s Disease] (PD), and [https://en.wikipedia.org/wiki/Amyotrophic_lateral_sclerosis Amyotrophic Lateral Sclerosis] (ALS)<ref name="Crupi">PMID:30800054</ref>. Also, due to the key role of glutamate in the brain, mGlus are also being studied for their role in psychiatric disorders like [https://en.wikipedia.org/wiki/Anxiety anxiety] and [https://en.wikipedia.org/wiki/Depression_(mood) depression]<ref name="Crupi">PMID:30800054</ref>. In many of these diseases, the overexpression of glutamate can lead to the overstimulation of mGlus and excitotoxicity <ref name="Bordi">PMID:10416961</ref>. However, an exception to this is the under stimulation of mGlus which can result in schizophrenia<ref name="Conn">PMID:19058862</ref>.  Research is ongoing, but studies have proven that agonists, antagonists, PAMs, and NAMs of mGlus are potential treatments for these diseases<ref name="Crupi">PMID:30800054</ref>.
+Glutamate is a major neurotransmitter in the brain and is known for its role in memory, synaptic plasticity, and neuronal development<ref name="Crupi">PMID:30800054</ref>. Thus, mGlus are located throughout the CNS and play key roles in various neurodegenerative diseases such as [https://en.wikipedia.org/wiki/Alzheimer%27s_disease Alzheimer's Disease] (AD), [https://en.wikipedia.org/wiki/Huntington%27s_disease Huntington's Disease] (HD), [https://en.wikipedia.org/wiki/Parkinson%27s_disease Parkinson’s Disease] (PD), and [https://en.wikipedia.org/wiki/Amyotrophic_lateral_sclerosis Amyotrophic Lateral Sclerosis] (ALS)<ref name="Crupi">PMID:30800054</ref>. Also, due to the key role of glutamate in the brain, mGlus are also being studied for their role in psychiatric disorders like [https://en.wikipedia.org/wiki/Anxiety anxiety] and [https://en.wikipedia.org/wiki/Depression_(mood) depression]<ref name="Crupi">PMID:30800054</ref>. In many of these diseases, the overexpression of glutamate can lead to the overstimulation of mGlus and excitotoxicity <ref name="Bordi">PMID:10416961</ref>. However, an exception to this is the under stimulation of mGlus which can result in [https://en.wikipedia.org/wiki/Schizophrenia schizophrenia]<ref name="Conn">PMID:19058862</ref>.  Research is ongoing, but studies have proven that agonists, antagonists, PAMs, and NAMs of mGlus are potential treatments for these diseases<ref name="Crupi">PMID:30800054</ref>.
 == 3D Structures ==