Sandbox Reserved 1716: Difference between revisions
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In the liver, the VKOR enzyme is set in the endoplasmic reticulum membrane (Fig.2). The transmembrane helices are located in the Endoplasmic Reticulum Luminal Region, which is the region between the ER Lumen and the [https://en.wikipedia.org/wiki/Cytosol Cytosol]. The cap region is partially oriented in the ER Lumen. The active site remains within the [https://en.wikipedia.org/wiki/Endoplasmic_reticulum Endoplasmic Reticulum Membrane].The Anchor is partially within the ER lumen, and partially embedded in the ER membrane. The anchor is what attaches the cap domain and stabilizes it, which allows the cap domain to cover the active site.<ref name="Liu">PMID:33154105</ref> | In the liver, the VKOR enzyme is set in the endoplasmic reticulum membrane (Fig.2). The transmembrane helices are located in the Endoplasmic Reticulum Luminal Region, which is the region between the ER Lumen and the [https://en.wikipedia.org/wiki/Cytosol Cytosol]. The cap region is partially oriented in the ER Lumen. The active site remains within the [https://en.wikipedia.org/wiki/Endoplasmic_reticulum Endoplasmic Reticulum Membrane].The Anchor is partially within the ER lumen, and partially embedded in the ER membrane. The anchor is what attaches the cap domain and stabilizes it, which allows the cap domain to cover the active site.<ref name="Liu">PMID:33154105</ref> | ||
The VKOR enzyme is made up of four transmembrane helices: <scene name='90/904321/Tm1/1'>TM1</scene>, <scene name='90/904321/Tm2/2'>TM2</scene>, <scene name='90/904321/Tm3/2'>TM3</scene>, and <scene name='90/904321/Tm4/2'>TM4</scene> .(Grey/Orange) Each of these helices come together to form a central ligand binding pocket. This central pocket is the active site where conserved Cysteines: C132 and C135 are located. In the cap domain are important regions that are significant for Vitamin K binding, and the overall function of Vitamin K Epoxide Reductase, including the Anchor(Green), Cap Sequence (Blue), Beta Hairpin (Purple), and 3-4 Loop (Pink). <ref name="Liu"/> | The VKOR enzyme is made up of four transmembrane helices (Fig.2): <scene name='90/904321/Tm1/1'>TM1</scene>, <scene name='90/904321/Tm2/2'>TM2</scene>, <scene name='90/904321/Tm3/2'>TM3</scene>, and <scene name='90/904321/Tm4/2'>TM4</scene> .(Grey/Orange) Each of these helices come together to form a central ligand binding pocket. This central pocket is the active site where conserved Cysteines: C132 and C135 are located. In the cap domain are important regions that are significant for Vitamin K binding, and the overall function of Vitamin K Epoxide Reductase, including the Anchor(Green), Cap Sequence (Blue), Beta Hairpin (Purple), and 3-4 Loop (Pink). <ref name="Liu"/> | ||
The <scene name='90/904321/Anchor/3'>Anchor</scene> attaches to the cap domain of the Vitamin K Epoxide Reductase Enzyme and is partially embedded in the Endoplasmic Reticulum Membrane. This both stabilizes the enzyme in the membrane, and stabilizes the cap domain over the active site. <ref name="Liu"/> | The <scene name='90/904321/Anchor/3'>Anchor</scene> attaches to the cap domain of the Vitamin K Epoxide Reductase Enzyme and is partially embedded in the Endoplasmic Reticulum Membrane. This both stabilizes the enzyme in the membrane, and stabilizes the cap domain over the active site. <ref name="Liu"/> | ||
