Sandbox Reserved 1716: Difference between revisions
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===Step II=== | ===Step II=== | ||
After Vitamin K Epoxide enters through the isoprenyl-chain tunnel, this begins <scene name='90/904321/Ii/3'>Step II</scene>. This binding induces a conformation change that "closes" the enzyme.Asn80 on TM2 and Tyr139 on TM4 <scene name='90/904322/Vko_binding/2'>hydrogen bonds</scene> to Vitamin K Epoxide. When Vitamin K Epoxide binds, | After Vitamin K Epoxide enters through the isoprenyl-chain tunnel, this begins <scene name='90/904321/Ii/3'>Step II</scene>. This binding induces a conformation change that "closes" the enzyme.Asn80 on TM2 and Tyr139 on TM4 <scene name='90/904322/Vko_binding/2'>hydrogen bonds</scene> to Vitamin K Epoxide. When Vitamin K Epoxide binds, the orientation of amino acid residues in between the cap domain, beta hairpin, anchor stabilize the closed conformation of VKOR. <scene name='90/904321/Vkobound_cys/4'>Cys135</scene> also forms a covalent bond with the 3' OH group on Vitamin K Epoxide. | ||
===Step III=== | ===Step III=== | ||
