Sandbox Reserved 1722: Difference between revisions

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[[Image:Drugs_and_zinc.PNG|450px|right|thumb|'''Figure 4''': Structures of (R)-Zinc-3573, Dextromethorphan, Morphine, and Codeine. The red circles indicate conserved basic N-dimethyl group and the blue squares show the conserved benzene rings.<ref name="Cao"/>]]

Many drugs have been linked to the activation of MRGPRX2 as a side effect that causes the sensation of itchiness. <ref name="Cao"/> Among these drugs are [https://en.wikipedia.org/wiki/Morphine morphine], [https://en.wikipedia.org/wiki/Codeine codeine], and [[https://en.wikipedia.org/wiki/Dextromethorphan dextromethorphan]]. These drugs contain chemical features similar to agonist R-Zinc-3573 (see Figure 4). They contain a conserved benzene ring that stabilizes them in binding pocket one (See Figure 3). Similarly, they contain an N-dimethyl group that would allow them to form key bonds with residues Asp-184 and Glu-164. Lastly, these drugs have a similar shape and size to that of the agonist R-Zinc-3573.<ref name="Babina"> Babina, M., et al. "MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway." Journal of Investigative Dermatology, 141(6), 1286-1296. https://doi.org/10.1016/j.jid.2020.09.017</ref>

Many drugs have been linked to the activation of MRGPRX2 as a side effect that causes the sensation of itchiness. <ref name="Cao"/> Among these drugs are [https://en.wikipedia.org/wiki/Morphine morphine], [https://en.wikipedia.org/wiki/Codeine codeine], and [https://en.wikipedia.org/wiki/Dextromethorphan dextromethorphan]. These drugs contain chemical features similar to agonist R-Zinc-3573 (see Figure 4). They contain a conserved benzene ring that stabilizes them in binding pocket one (See Figure 3). Similarly, they contain an N-dimethyl group that would allow them to form key bonds with residues Asp-184 and Glu-164. Lastly, these drugs have a similar shape and size to that of the agonist R-Zinc-3573.<ref name="Babina"> Babina, M., et al. "MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway." Journal of Investigative Dermatology, 141(6), 1286-1296. https://doi.org/10.1016/j.jid.2020.09.017</ref>

Currently, research is being conducted to understand how to mediate the effects of MRGPRX2. This receptor is shallow and is able to bind to a variety of drugs, and its activation results in the sensation of itching. If this problem could be solved this secondary side-effect from drugs could be avoided and could aid in patient satisfaction with medication.

Sandbox Reserved 1722: Difference between revisions

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@@ Line 69: / Line 69: @@
 [[Image:Drugs_and_zinc.PNG|450px|right|thumb|'''Figure 4''': Structures of (R)-Zinc-3573, Dextromethorphan, Morphine, and Codeine. The red circles indicate conserved basic N-dimethyl group and the blue squares show the conserved benzene rings.<ref name="Cao"/>]]
-Many drugs have been linked to the activation of MRGPRX2 as a side effect that causes the sensation of itchiness. <ref name="Cao"/> Among these drugs are [https://en.wikipedia.org/wiki/Morphine morphine], [https://en.wikipedia.org/wiki/Codeine codeine], and [[https://en.wikipedia.org/wiki/Dextromethorphan dextromethorphan]]. These drugs contain chemical features similar to agonist R-Zinc-3573 (see Figure 4). They contain a conserved benzene ring that stabilizes them in binding pocket one (See Figure 3). Similarly, they contain an N-dimethyl group that would allow them to form key bonds with residues Asp-184 and Glu-164. Lastly, these drugs have a similar shape and size to that of the agonist R-Zinc-3573.<ref name="Babina"> Babina, M., et al. "MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway." Journal of Investigative Dermatology, 141(6), 1286-1296. https://doi.org/10.1016/j.jid.2020.09.017</ref>
+Many drugs have been linked to the activation of MRGPRX2 as a side effect that causes the sensation of itchiness. <ref name="Cao"/> Among these drugs are [https://en.wikipedia.org/wiki/Morphine morphine], [https://en.wikipedia.org/wiki/Codeine codeine], and [https://en.wikipedia.org/wiki/Dextromethorphan dextromethorphan]. These drugs contain chemical features similar to agonist R-Zinc-3573 (see Figure 4). They contain a conserved benzene ring that stabilizes them in binding pocket one (See Figure 3). Similarly, they contain an N-dimethyl group that would allow them to form key bonds with residues Asp-184 and Glu-164. Lastly, these drugs have a similar shape and size to that of the agonist R-Zinc-3573.<ref name="Babina"> Babina, M., et al. "MRGPRX2 Is the Codeine Receptor of Human Skin Mast Cells: Desensitization through β-Arrestin and Lack of Correlation with the FcεRI Pathway." Journal of Investigative Dermatology, 141(6), 1286-1296. https://doi.org/10.1016/j.jid.2020.09.017</ref>
 Currently, research is being conducted to understand how to mediate the effects of MRGPRX2. This receptor is shallow and is able to bind to a variety of drugs, and its activation results in the sensation of itching. If this problem could be solved this secondary side-effect from drugs could be avoided and could aid in patient satisfaction with medication.