Sandbox Reserved 1723: Difference between revisions
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===== Small Molecule ===== | ===== Small Molecule ===== | ||
<scene name='90/904328/Zinc/4'>(R)-Zinc-3573</scene> is a cation ligand that selectively binds to MRGPRX2 (Figure 3). Its N-dimethyl is inserted into subpocket 1 of the binding cavity with aromatic amino acid residues Phe-170, Trp-243, and Phe-244. In this<scene name='90/904328/Zizwithaa/ | <scene name='90/904328/Zinc/4'>(R)-Zinc-3573</scene> is a cation ligand that selectively binds to MRGPRX2 (Figure 3). Its N-dimethyl is inserted into subpocket 1 of the binding cavity with aromatic amino acid residues Phe-170, Trp-243, and Phe-244. In this <scene name='90/904328/Zizwithaa/5'>cavity</scene>, N-dimethyl group on the ligand makes ion pairs with Asp-184 and Glu-164. The ligand is then stabilized by stacking its ring with Trp-248 and the Cys-168 to Cys-180 disulfide bond <ref name="Yang">Yang, Fan, et al. "Structure, function and pharmacology of human itch receptor complexes." Nature, Nature Publishing Group, 17 November 2021, https://www.nature.com/articles/s41586-021-04077-y</ref>. | ||
===== Peptide ===== | ===== Peptide ===== | ||
