Sandbox Reserved 1723: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 30: | Line 30: | ||
==== ''PIF Motif'' ==== | ==== ''PIF Motif'' ==== | ||
MRGPRX2 also differs from typical Class A GPCRs based on substitutions in the PIF/connector motif, which acts as a microswitch. PIF plays a role in connecting the binding pocket to conformational rearrangements required for receptor activation<ref name="Schonegge">Schonegge, Anne-Marie, et al. "Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity." Nature, Nature Publishing Group, 18 December 2017, https://www.nature.com/articles/s41467-017-02257-x</ref>. The PIF motif is located towards the base of the TM domains. In a Class A GPCR, like β2AR, the <scene name='90/904327/B2arpif_pt_2/1'>PIF motif</scene> consists of Phe-211, Ile-121, and Phe-282 on TM domains 5, 3, and 6, respectively. However, for MRGPRX2, this <scene name='90/ | MRGPRX2 also differs from typical Class A GPCRs based on substitutions in the PIF/connector motif, which acts as a microswitch. PIF plays a role in connecting the binding pocket to conformational rearrangements required for receptor activation<ref name="Schonegge">Schonegge, Anne-Marie, et al. "Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity." Nature, Nature Publishing Group, 18 December 2017, https://www.nature.com/articles/s41467-017-02257-x</ref>. The PIF motif is located towards the base of the TM domains. In a Class A GPCR, like β2AR, the <scene name='90/904327/B2arpif_pt_2/1'>PIF motif</scene> consists of Phe-211, Ile-121, and Phe-282 on TM domains 5, 3, and 6, respectively. However, for MRGPRX2, this <scene name='90/904327/Mxpifnolabel_pt_3/1'>PIF motif</scene> is replaced with Leu-194 on TM5, Leu-117 on TM3, and Phe-232 on TM6. | ||
==== ''DRY Motif'' ==== | ==== ''DRY Motif'' ==== | ||
