Neurofibromin: Difference between revisions
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<StructureSection load='' scene='90/904325/Introductory_image_full/2' size='340' side='right' caption='Neurofibromin [https://www.rcsb.org/structure/7PGS (7pgs)] Homo dimeric structure colored to differentiate dimers'> | |||
== Introduction == | == Introduction == | ||
<scene name='90/904325/Introductory_image_full/1'>Neurofibromin</scene> (NF) is a cytoplasmic protein encoded by the ''NF1'' gene located on chromosome 17 <ref name= "Bergoug">PMID:33121128</ref>. It is localized to the cell membrane by the [https://en.wikipedia.org/wiki/SPRED1 SPRED 1] protein<ref name= "Naschberger">PMID:34707296</ref>. The neurofibromin protein in encoded by over 350 kb of DNA and contains 62 exons, 58 of which are constitutive<ref name= ''Trovó-Marqui''>PMID:16813595</ref>. NF suppresses the <scene name='90/904325/Ras_neurofibromin_overview/1'>Ras</scene> oncogene by increasing the rate of hydrolysis from <scene name='90/904325/Arginine_finger_and_gtp/3'>Ras bound to GTP</scene> (active) to <scene name='90/904325/Arginine_finger_and_gdp/4'>Ras bound to GDP</scene> (inactive)<ref name= ''Hall''>PMID:12213964</ref>. Increasing the rate of Ras inactivation decreases cell proliferation linked to cancer<ref name= ''Cimino''>PMID:29478615</ref>. | <scene name='90/904325/Introductory_image_full/1'>Neurofibromin</scene> (NF) is a cytoplasmic protein encoded by the ''NF1'' gene located on chromosome 17 <ref name= "Bergoug">PMID:33121128</ref>. It is localized to the cell membrane by the [https://en.wikipedia.org/wiki/SPRED1 SPRED 1] protein<ref name= "Naschberger">PMID:34707296</ref>. The neurofibromin protein in encoded by over 350 kb of DNA and contains 62 exons, 58 of which are constitutive<ref name= ''Trovó-Marqui''>PMID:16813595</ref>. NF suppresses the <scene name='90/904325/Ras_neurofibromin_overview/1'>Ras</scene> oncogene by increasing the rate of hydrolysis from <scene name='90/904325/Arginine_finger_and_gtp/3'>Ras bound to GTP</scene> (active) to <scene name='90/904325/Arginine_finger_and_gdp/4'>Ras bound to GDP</scene> (inactive)<ref name= ''Hall''>PMID:12213964</ref>. Increasing the rate of Ras inactivation decreases cell proliferation linked to cancer<ref name= ''Cimino''>PMID:29478615</ref>. | ||
