Thymidylate synthase: Difference between revisions
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==Inhibition== | ==Inhibition== | ||
Methotrexate, a competitive inhibitor competes with folate substrate to bind to the active site of TS. Inhibits the conversion of CH<sub>2</sub>H<sub>4</sub>F to H<sub>2</sub>F. This inhibition stops the conversion of products to reactants, stopping cellular reproduction. <scene name='49/493689/Inhibited/ | Methotrexate, a competitive inhibitor competes with folate substrate to bind to the active site of TS. Inhibits the conversion of CH<sub>2</sub>H<sub>4</sub>F to H<sub>2</sub>F. This inhibition stops the conversion of products to reactants, stopping cellular reproduction. <scene name='49/493689/Inhibited/2'>inhibits</scene> TS. | ||
The image below shows folic acid on the top and the inhibitor methotrexate on the bottom | The image below shows folic acid on the top and the inhibitor methotrexate on the bottom | ||
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==3D structures of thymidylate synthase== | ==3D structures of thymidylate synthase== | ||
[[Thymidylate synthase 3D structures]] | [[Thymidylate synthase 3D structures]] | ||
==Acknowledgements== | |||
== References == | == References == | ||
