GLUT1: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 13: | Line 13: | ||
== Disease == | == Disease == | ||
=== | ===Malignancy=== | ||
Oncogenes such as Ras and Src have been shown to upregulate GLUT1 in rat tumors. GLUT1 has also been consistently shown to be upregulated in malignancies of the breast.<ref>PMID:15389572</ref> Increased glucose utilization by upregulation of the non-insulin dependent GLUT1 transporter increases cancer cell proliferation and rates of glycolysis in tumors. | Oncogenes such as Ras and Src have been shown to upregulate GLUT1 in rat tumors. GLUT1 has also been consistently shown to be upregulated in malignancies of the breast.<ref>PMID:15389572</ref> Increased glucose utilization by upregulation of the non-insulin dependent GLUT1 transporter increases cancer cell proliferation and rates of glycolysis in tumors. | ||
