ALDH2: Difference between revisions
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== Introduction == | == Introduction == | ||
Mitochondrial aldehyde dehydrogenase (ALDH2) is a single member of ALDH2 family and one of 19 members of ALDH superfamily. It is responsible for metabolism of acetaldehyde, typical metabolite from alcohol consumption, and other aldehydes. It is expressed in variety of tissues with highest level found in liver. Its’ cytosolic isoform has 70% sequence identity. Chromosomal location of ALDH2 is on 12q24.2. Polymorphism in the ALDH2 gene is related to development of alcohol-induced cancer and decreased risk of alcoholism.<ref>DOI:10.1186/1479-7364-2-2-138</ref> ALDH2 gene is 44kpbs long with 13 exons.<ref>DOI:10.1074/jbc.M606477200</ref> | |||
== Structure == | == Structure == | ||
<StructureSection load='3N80' size='350' side='right' caption='Human mitochondrial aldehyde dehydrogenase, apo form (PDB entry [http://doi.org/10.2210/pdb3N80/pdb 3N80])' scene=''> | <StructureSection load='3N80' size='350' side='right' caption='Human mitochondrial aldehyde dehydrogenase, apo form (PDB entry [http://doi.org/10.2210/pdb3N80/pdb 3N80])' scene=''> | ||
