Methionine synthase: Difference between revisions
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== Cobalamin binding == | == Cobalamin binding == | ||
[[Image:cob_1_alamin.jpeg| | [[Image:cob_1_alamin.jpeg|300px]] | ||
The Cobalamin binding domain has a special characteristic in that, it is most naturally found in a protective conformation to prevent unwanted chemistry from occurring (PDB: 1BMT). This is referred to as a 'capping' mechanism. | The Cobalamin binding domain has a special characteristic in that, it is most naturally found in a protective conformation to prevent unwanted chemistry from occurring (PDB: 1BMT). This is referred to as a 'capping' mechanism. | ||
DMB, in the lower ligand of the <scene name='90/907471/Bindingdomain2/1'>B12 binding domain</scene> is displaced from the Cobalt by a Histidine residue to be 'uncapped' to form Me-Cob(III)alamin. | |||
