GLUT1: Difference between revisions
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===Brain=== | ===Brain=== | ||
The GLUT1 transporter works synergistically with other solute carriers in the brain. Astrocytes and endothelial cells of brain capillaries primarily express GLUT1; neurons primarily express [[Glut3]]. GLUT1 has a relatively high Km and is upregulated in times of hypoglycemia in the brain to ensure adequate glucose uptake. [[Glut3]] has a low Km to ensure a steady supply of glucose for neurons even when extracellular glucose concentrations are low.<ref>PMID:32789766</ref> GLUT1, [[Glut3]], and glycogen storage by astrocytes | The GLUT1 transporter works synergistically with other solute carriers in the brain. Astrocytes and endothelial cells of brain capillaries primarily express GLUT1; neurons primarily express [[Glut3]]. GLUT1 has a relatively high Km and is upregulated in times of hypoglycemia in the brain to ensure adequate glucose uptake. [[Glut3]] has a low Km to ensure a steady supply of glucose for neurons even when extracellular glucose concentrations are low.<ref>PMID:32789766</ref> GLUT1, [[Glut3]], and glycogen storage by astrocytes all work in conjunction with monocarboxylate transporters (MCTs) to supply the neurons with energy-providing substrates such as lactate.<ref>PMID:29076603</ref> | ||
[[Image:Blood-brain_barrier.png]] | [[Image:Blood-brain_barrier.png]] | ||
