GLUT1: Difference between revisions
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===Cancer=== | ===Cancer=== | ||
Oncogenes such as Ras and Src have been linked to upregulation of GLUT1 in rat tumors. Many studies have shown that GLUT1 is upregulated in malignancies of the breast.<ref>PMID:15389572</ref> Upregulation of the GLUT1 transporter has been shown to increase cell proliferation in some types of breast cancer.<ref>PMID:27931517</ref> GLUT1 upregulation is thought to play a role in malignant cell proliferation in some types of tumors.<ref>PMID:31324056</ref> | Oncogenes such as Ras and Src have been linked to upregulation of GLUT1 in rat tumors. Many studies have shown that GLUT1 is upregulated in malignancies of the breast.<ref>PMID:15389572</ref> Upregulation of the GLUT1 transporter has been shown to increase cell proliferation in some types of breast cancer.<ref>PMID:27931517</ref> GLUT1 upregulation is thought to play a role in malignant cell proliferation in some types of tumors.<ref>PMID:31324056</ref> | ||
===Diabetes=== | |||
====Diabetes and Pregnancy==== | |||
GLUT1 has been shown to be upregulated in the placental tissue of mothers with both pregestational and gestational diabetes, even when a patient's glycemic control is good. It is hypothesized that fetal hyperglycemia due to increased glucose transporter expression.<ref>PMID:10022440</ref> | |||
== Relevance == | == Relevance == | ||
