User:Brian Boyle/Sandbox 1: Difference between revisions

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== '''BRPF1 Association with the MOZ HAT Complex''' ==
== '''BRPF1 Association with the MOZ HAT Complex''' ==
Surrounding the PZP domain, there are two non-chromatin-binding modules that are responsible for BRPF1's association in the MOZ HAT Complex. On the N-terminal side of the PZP, lies the MOZ/MORF binding domain<ref name="Lalonde">PMID:24065767</ref>. On the other side of the PZP domain, there is a small module involved in binding to ING5 and MEAF6 (two other subunit of the MOZ HAT Complex)<ref name="Ullah">PMID:18794358</ref>.
The MOZ Histone Acetyltransferase Complex is a tetramer consisting of MEAF6, ING5, BRPF1 (or BRPF2/BRPF3) and MOZ (or MORF)<ref name="Klein">PMID:31711755</ref>. Within BRPF1, there are two non-chromatin-binding modules surrounding the PZP domain that are responsible for its association with the MOZ HAT Complex. On the N-terminal side of the PZP, lies the MOZ/MORF binding domain<ref name="Lalonde">PMID:24065767</ref>. On the other side of the PZP domain, there is a small module involved in binding to ING5 and MEAF6<ref name="Ullah">PMID:18794358</ref>. BRPF1 seems to be required for the formation of the MOZ HAT complex, as it acts as a bridge associating MOZ or MORF with ING5 and MEAF6<ref name ="Ullah" />.


== '''Role in Disease Progression''' ==
== '''Links to Human Disease''' ==
BRPF1 has been implicated in the progression of several cancers. Chromosomal translocations of the gene encoding BRPF1 have been linked to the development of acute myeloid leukemia <ref name="Obi" />. Another study reported an association between upregulation of the BRPF1 gene and poor survival rates in hepatocellular carcinoma patients <ref>PMID:34285329</ref>.     
BRPF1 has been implicated in the progression of several cancers. Chromosomal translocations of the gene encoding MOZ (a subunit in the MOZ HAT complex) have been linked to the development of acute myeloid leukemia <ref name="Obi" />. The crucial role of BRPF1 in this complex has made it the subject of many studies in order to understand how this mutation leads to a cancer phenotype. Another study reported an association between upregulation of the BRPF1 gene and poor survival rates in hepatocellular carcinoma patients <ref>PMID:34285329</ref>.     


Mutations within the gene itself have been associated with neurological disorders and widespread reduced histone acetylation <ref name="Yan" />.
Mutations within the gene itself have been associated with neurological disorders and widespread reduced histone acetylation <ref name="Yan" />.
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