GLUT1: Difference between revisions

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== Classification ==

GLUT proteins, encoded by the SLC2 genes, are part of the Major Facilitator Superfamily (MFS) of substrate transporters. Structural elements characteristic of GLUT proteins are twelve transmembrane domains, one N-linked glycosylation site, and lengths of about five-hundred amino acids.<ref>PMID:23506862</ref> GLUT proteins transport a variety of monosaccharides that enable cellular respiration and are thus abundant in the body. ~~According to~~ the [http://cathdb.info/version/v4_3_0/superfamily/1.20.1250.20 CATH] classification database, the MFS superfamily has 23,982 unique species and 134 characteristic domains. GLUT1 has two highly-conserved ATP-binding domains known as Walker motifs A and B.<ref>PMID:15326030</ref> A third ATP-binding domain is less conserved. According to [https://www.uniprot.org/uniprot/?query=job:P2022050392C7BAECDB1C5C413EE0E0348724B682005B3CL&columns=id,entry%20name,reviewed,protein%20names,genes,organism,length,peptidesearch(P2022050392C7BAECDB1C5C413EE0E0348724B682005B3CL) UniProt], these specific sequences in the GLUT1 transporter are shared among glucose transporters in several different organisms.

GLUT proteins, encoded by the SLC2 genes, are part of the Major Facilitator Superfamily (MFS) of substrate transporters. Structural elements characteristic of GLUT proteins are twelve transmembrane domains, one N-linked glycosylation site, and lengths of about five-hundred amino acids.<ref>PMID:23506862</ref> GLUT proteins transport a variety of monosaccharides that enable cellular respiration and are thus abundant in the body. Referencing the [http://cathdb.info/version/v4_3_0/superfamily/1.20.1250.20 CATH] classification database, the MFS superfamily has 23,982 unique species and 134 characteristic domains. GLUT1 has two highly-conserved ATP-binding domains known as Walker motifs A and B.<ref>PMID:15326030</ref> A third ATP-binding domain is less conserved. According to [https://www.uniprot.org/uniprot/?query=job:P2022050392C7BAECDB1C5C413EE0E0348724B682005B3CL&columns=id,entry%20name,reviewed,protein%20names,genes,organism,length,peptidesearch(P2022050392C7BAECDB1C5C413EE0E0348724B682005B3CL) UniProt], these specific sequences in the GLUT1 transporter are shared among glucose transporters in several different organisms.

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 <StructureSection load='4pyp' size='340' side='right' caption='Crystal structure 4PYP from PDB' scene=''>
 == Classification ==
-GLUT proteins, encoded by the SLC2 genes, are part of the Major Facilitator Superfamily (MFS) of substrate transporters. Structural elements characteristic of GLUT proteins are twelve transmembrane domains, one N-linked glycosylation site, and lengths of about five-hundred amino acids.<ref>PMID:23506862</ref> GLUT proteins transport a variety of monosaccharides that enable cellular respiration and are thus abundant in the body. According to the [http://cathdb.info/version/v4_3_0/superfamily/1.20.1250.20 CATH] classification database, the MFS superfamily has 23,982 unique species and 134 characteristic domains. GLUT1 has two highly-conserved ATP-binding domains known as Walker motifs A and B.<ref>PMID:15326030</ref> A third ATP-binding domain is less conserved. According to [https://www.uniprot.org/uniprot/?query=job:P2022050392C7BAECDB1C5C413EE0E0348724B682005B3CL&columns=id,entry%20name,reviewed,protein%20names,genes,organism,length,peptidesearch(P2022050392C7BAECDB1C5C413EE0E0348724B682005B3CL) UniProt], these specific sequences in the GLUT1 transporter are shared among glucose transporters in several different organisms.
+GLUT proteins, encoded by the SLC2 genes, are part of the Major Facilitator Superfamily (MFS) of substrate transporters. Structural elements characteristic of GLUT proteins are twelve transmembrane domains, one N-linked glycosylation site, and lengths of about five-hundred amino acids.<ref>PMID:23506862</ref> GLUT proteins transport a variety of monosaccharides that enable cellular respiration and are thus abundant in the body. Referencing the [http://cathdb.info/version/v4_3_0/superfamily/1.20.1250.20 CATH] classification database, the MFS superfamily has 23,982 unique species and 134 characteristic domains. GLUT1 has two highly-conserved ATP-binding domains known as Walker motifs A and B.<ref>PMID:15326030</ref> A third ATP-binding domain is less conserved. According to [https://www.uniprot.org/uniprot/?query=job:P2022050392C7BAECDB1C5C413EE0E0348724B682005B3CL&columns=id,entry%20name,reviewed,protein%20names,genes,organism,length,peptidesearch(P2022050392C7BAECDB1C5C413EE0E0348724B682005B3CL) UniProt], these specific sequences in the GLUT1 transporter are shared among glucose transporters in several different organisms.
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