User:Brian Boyle/Sandbox 1: Difference between revisions
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The MOZ Histone Acetyltransferase Complex is a tetramer consisting of MEAF6, ING5, BRPF1 and MOZ or MORF<ref name="Klein" />. Within BRPF1, there are two non-chromatin-binding modules surrounding the PZP domain that are responsible for its association with the MOZ HAT Complex. On the N-terminal side of the PZP, lies the MOZ/MORF binding domain<ref name="Lalonde">PMID:24065767</ref>. On the other side of the PZP domain, there is a small module involved in binding to ING5 and MEAF6<ref name="Ullah">PMID:18794358</ref>. BRPF1 seems to be required for the formation of the MOZ HAT complex, as it acts as a bridge associating MOZ or MORF with ING5 and MEAF6<ref name ="Ullah" />. | The MOZ Histone Acetyltransferase Complex is a tetramer consisting of MEAF6, ING5, BRPF1 and MOZ or MORF<ref name="Klein" />. Within BRPF1, there are two non-chromatin-binding modules surrounding the PZP domain that are responsible for its association with the MOZ HAT Complex. On the N-terminal side of the PZP, lies the MOZ/MORF binding domain<ref name="Lalonde">PMID:24065767</ref>. On the other side of the PZP domain, there is a small module involved in binding to ING5 and MEAF6<ref name="Ullah">PMID:18794358</ref>. BRPF1 seems to be required for the formation of the MOZ HAT complex, as it acts as a bridge associating MOZ or MORF with ING5 and MEAF6<ref name ="Ullah" />. | ||
== ''' | == '''Evolutionary Relationships''' == | ||
Bromodomains are categorized into several families based on sequence and structural similarity. The BRPF1 bromodomain belongs to family IV of bromodomains<ref name="Lloyd">PMID:28500727</ref>. | Bromodomains are categorized into several families based on sequence and structural similarity. The BRPF1 bromodomain belongs to family IV of bromodomains<ref name="Lloyd">PMID:28500727</ref>. | ||
